DNA encoding mammalian phosphodiesterases

Details DNA encoding mammalian phosphodiesterases DNA encoding mammalian phosphodiesterases

1992-04-20

1995-02-14

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435196, 435199, 4352401, 4352523, 43525411, 4353201, 536 232, C12N 916, C12N 1509, C12N 1555, C12N 1563

Patent

active

053895274

ABSTRACT:
The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.

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