Cell lines comprising sour-taste receptors

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S069100, C435S252300, C435S320100, C435S471000

Reexamination Certificate

active

08003384

ABSTRACT:
The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.

REFERENCES:
patent: 6608176 (2003-08-01), Chaudhari
patent: 6955887 (2005-10-01), Adler et al.
patent: 7223551 (2007-05-01), Adler
patent: 7297543 (2007-11-01), Zoller
patent: 7309577 (2007-12-01), Zoller
patent: 7344859 (2008-03-01), Zoller
patent: 7364867 (2008-04-01), Margolskee
patent: 7364903 (2008-04-01), Zoller
patent: 7399601 (2008-07-01), Adler
patent: 2002/0164645 (2002-11-01), Zuker
patent: 2004/0132075 (2004-07-01), Elliot et al.
patent: 2004/0132134 (2004-07-01), Adler
patent: 2004/0171042 (2004-09-01), Adler
patent: 2004/0209286 (2004-10-01), Adler
patent: 2004/0248123 (2004-12-01), Drayna
patent: 2005/0287517 (2005-12-01), Adler
patent: 2006/0019346 (2006-01-01), Xu
patent: 2009/0089888 (2009-04-01), Zuker et al.
Ugawa S. Anatomical Science International 78:205-210, 2003.
Adler et al., 2000, “A Novel Family of Mammalian Taste Receptors,” Cell 100:693-702.
Barr and Sternberg, “A polycystic kidney-disease gene homologue required for male mating behavior inC. elegans,” 1999, Nature 401:386-389.
Barr et al., 2001, “TheCaenorhabditis elegansautosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway,” Curr. Biol. 11:1341-1346.
Behrens, et al., “Members of RTP and REEP Gene Families Influence Functional Bitter Taste Receptor Expression,” The Journal of Biological Chemistry, vol. 281, No. 29, pp. 20650-20659, Jul. 21, 2006.
Chandrashekar et al., 2000, “T2Rs Function as Bitter Taste Receptors,” Cell 100:703-711.
Chen et al., 1999, “Polycystin-L is a calcium-regulated cation channel permeable to calcium ions,” Nature 401:386-386.
Clapham, 2003, “TRP channels as cellular sensors,” Nature 426:517-524.
Clapp et al., 2001, “Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction,” Neurosci. 2:6.
Corey et al., 2004, “TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells,” Nature 432:723-730.
Damak et al., 2003, “Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3,” Science 301:850-853.
Delmas et al., 2004, “Polycystins, calcium signaling, and human diseases,” Biochem. Biophys. Res. Commun. 322:1374-1383.
Faus, 2000, “Recent developments in the characterization and biotechnological production of sweet-tasting proteins,” Appl. Microbiol. Biotechnol. 53:145-151.
Ganzevles and Kroeze, 1987, “Effects of Adaptation and Cross-Adaptation to Common Ions on Sourness Intensity,” Physiol. Behav. 40:641-646.
Gonzalez-Perrett et al., 2001, “Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel,” Proc. Natl. Acad. Sci. 98:1182-1187.
Guo et al., 2000, “Identification and Characterization of a Novel Polycystin Family Member . . . ”, Genomics 241-251.
Hanaoka et al., “Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents,” 2000, Nature 408:990-994.
Hughes et al., 1999, “Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein,” Hum. Mol. Genet. 8:543-549.
International Search Report and Written Opinion from PCT/US2007/15288, Apr. 9, 2008.
Ishimaru, et al., “Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor,” PNAS, Aug. 15, 2006, vol. 103, No. 33, pp. 12569-12574.
Kitagawa et al., 2001, “Molecular Genetic Identification of a Candidate Receptor Gene for Sweet Taste,” Biochem. Biophys. Res. Comm. 283:236-242.
Kohmura et al., 2002, “Structure-taste relationships of the sweet protein monellin,” Pure Appl. Chem. 74:1235-1242.
Jones, “Golf: An Olfactory Neuron Specific-G Protein Involved in Odorant Siognal Transduction,” Science, May 19, 1989, vol. 244, pp. 790-795.
Li et al., 2002, “Human receptors for sweet and umami taste,” Proc. Natl. Acad. Sci. 99:4692-4693.
Li et al., 2003, “Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes,” Genomics 81:596-608.
Lindemann et al., 1996, “Taste Reception,” Physiol. Rev. 76:718-66.
Lingueglia et al., 1997, “A Modulatory Subunit of Acid Sensing Ion Channels in Brain and Dorsal Root Ganglion Cells,” J. Biol. Chem. 272:29778-29783.
Lopezjimenez, N.D., et al., “Two members of the TRPP family of ion channels, Pkd113 and Pkd211, are co-expressed in a subset of taste receptor cells,” J. Neurochemistry. Jul. 2006, vol. 98, pp. 68-77.
Ludwig et al., 1998, “A family of hyperpolarization-activated mammalian cation channels,” Nature 393:587-691.
Makhlouf and Blum, 1972, “Kinetics of the Taste Response to Chemical Stimulation: A Theory of Acid Taste in Man,” Gastroenterology 63:67-75.
Margolskee, 2002, “Molecular Mechanisms of Bitter and Sweet Taste Transduction,” J. Biol. Chem. 277:1-4.
Matsunami et al., 2000, “A family of candidate taste receptors in human and mouse,” Nature 404:601-604.
Max et al., 2001, “Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac,” Nat Genet. 28:58-63.
Miyamoto et al., 2000, “Acid and salt responses in mouse taste cells,” Prog. Neurobiol. 62:135-157.
Miyoshi et al., 2001, “IP3 receptor type 3 and PLCβ2 are co-expressed with taste receptors T1R and T2R in rat taste bud cells,” Chem Senses 26:259-265.
Montell, 2005 Sci. STKE (Feb. 22, 2005), “The TRP Superfamily of Cation Channels,”.
Montmayeur and Matsunami, 2002, “Receptors for bitter and sweet taste,” Curr Opin. Neurobiol. 12:366-371.
Montmayeur et al., 2001, “A candidate taste receptor gene near a sweet taste locus,” Nat. Neurosci 4:492-498.
Moosmang et al., 1999, “Differential Distribution of Four Hyperpolarization-Activated Cation Channels in Mouse Brain,” Biol. Chem. 380:975-980.
Mueller et al., 2005, “The receptors and coding logic for bitter taste,” Nature 434:225-229.
Nauli and Zhou, 2004, “Polycystins and mechanosensation in renal and nodal cilia,” Bioessays 26:844-856.
Nauli et al., 2003, “Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells,” Nat Genet. 33:129-137.
Nelson et al., 2001, “Mammalian Sweet Taste Receptors,” Cell 106:381-390.
Nelson et al., 2002, “An amino-acid taste receptor,” Nature 416:199-202.
Nomura et al., 1998, “Identification of PKDL, a Novel Polycystic Kidney Disease 2-Like Gene Whose Murine Homologue is Deleted in Mice with Kidney and Retinal Defects,” J. Biol. Chem. 273:25967-25973.
Perez et al., 2002, “A transient receptor potential channel expressed in taste receptor cells,” Nat. Neurosci. 5:1169-1176.
Richter, T.A., et al., “Sour taste stimuli evoke Ca2+ and pH responses in mouse taste cells, ”J. Physiol (2003) 547:2, pp. 475-483.
Richter et al., 2004, “Acid-Sensing Ion Channel-2 is Not Necessary for Sour Taste in Mice,” J. Neurosci. 24:4088-4091.
Scott, 2004, “The Sweet and the Bitter of Mammalian Taste,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cell lines comprising sour-taste receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cell lines comprising sour-taste receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell lines comprising sour-taste receptors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2780406

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.