Diacylglycerol O-acyltransferase 2α (DGAT2α)

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C435S007100, C435S193000, C435S069200, C530S387100, C530S388100, C530S387900, C424S130100, C424S141100

Reexamination Certificate

active

07862819

ABSTRACT:
Nucleic acid compositions encoding mammalian DGAT2α polypeptide products with diglyceride acyltransferase activity, as well as the mammalian DGAT2α polypeptide products encoded thereby and methods for producing the same, are provided. The subject DGAT2α polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.

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Database EMBL Online! EBI, Dec. 1, 2001, “Diacylglycerol acytransferase 2 (hypothetical protein)”, retrieved from EMBL, Database accession No. Q96PD7, XP002285959, see sequence.
Database EMBL Online! EBI; Oct. 8, 2001, “Homo sapiensdiacylglycerol O-acyltransferase homolog 2 (mouse), mRNA, (cDNA clone MGC: 17861 IMAGE:3903313)” retrieved from EMBL Database accession No. BC015234, XP002285960, see sequence.
Database EMBL Online! EBI; Jun. 1, 2001, “0610010B06Rik protein (Diacylglycerol acyltransferase 2”) retrieved from EMBL, Database accession No. Q9DCV3, XP002285961.
Farese, Robert V. Jr. et al., “Triglyceride synthesis: Insights from the cloning of diacylglycerol acyltransferase” Current Opinion in Lipidology, vol. 11, No. 3, Jun. 2000, pp. 229-234.
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Database EMBL EBI; Feb. 9, 2001. “Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4933405B12 product:diacylglyerol o-acyltransferase 2, full insert sequence.” retrieved from EMBL accession No. AKO16660.
Database EMBL [Onine] Feb. 8, 2001, “Musmusculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610010B06 product:diacylglycerol O-acyltransferase 2, full insert sequence.” retrieved from EBI accession No. EMBL:AK002443 Database accession No. AK002443.

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