Method of preparing thymosin .alpha..sub.1 and derivatives there

Details Method of preparing thymosin .alpha..sub.1 and derivatives there Method of preparing thymosin .alpha..sub.1 and derivatives there

1980-03-24

1982-10-12

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

043538215

ABSTRACT:
Polypeptides of the sequence Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Ly s-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, wherein at least one of the amino acids 10, 15, 21, 25 and/or 28 is present as amide or alkyl amide, and/or amino acid 1 bears an acyl group other than acetyl, having up to 6 carbon atoms, especially an acyl glycine residue. In addition, certain thymosin .alpha..sub.1 fragments I to VII are provided.

REFERENCES:
patent: 4079127 (1978-03-01), Goldstein et al.
patent: 4148788 (1979-04-01), Wang
I. Z. Siemion, et al., "Peptides", Proceedings of the Fifteenth European tide Symposium 1978.
Merrifield, Peptides (1978), 19 & 248-251.
Birr, et al., Angew Chem. Int. Ed. Engl. 18, (1979) 394;5.

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