Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-11-02
1997-06-17
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
530334, 530335, 536 253, C12Q 168
Patent
active
056396031
ABSTRACT:
A general stochastic method for synthesizing compounds can be used to generate large collections of tagged compounds that can be screened to identify and isolate compounds with useful properties.
REFERENCES:
patent: 4182654 (1980-01-01), Royer
patent: 4315074 (1982-02-01), Royer
patent: 4587044 (1986-05-01), Miller et al.
patent: 4631211 (1986-12-01), Houghton
patent: 4671941 (1987-06-01), Niina et al.
patent: 4701304 (1987-10-01), Horn et al.
patent: 4713326 (1987-12-01), Dattagupta
patent: 4755558 (1988-07-01), Kalbag
patent: 4794150 (1988-12-01), Steel
patent: 4818681 (1989-04-01), Dattagupta
patent: 4833092 (1989-05-01), Geysen
patent: 4855225 (1989-08-01), Fung et al.
patent: 4882269 (1989-11-01), Schneider et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5143854 (1992-09-01), Pirrung
patent: 5264563 (1993-11-01), Huse
patent: 5324483 (1994-06-01), Cody et al.
Advances in Analytical Chemistry and Instrumentation, Charles N. Reilley, Ed., John Wiley & Sons, Inc., 1964, pp. 56-59.
Frank et al., "Simultaneous Multiple Peptide Synthesis Under Continuous Flow Conditions on Cellulose Paper Discs as Segmental Solid Supports," Tetrahedron Letters (1988) 44:6031-6040.
Arnold et al., "Room-Temperature Microparticle-Based Persistent Spectral Hole Burning Memory," Optics Letters 16(6):420-422 (1991).
Baldwin et al., "New Photolabile Phosphate Protecting Groups," Tetrahedron 46(190:6879-6884 (1990).
Barr et al., "7-Deaza-2'-Deoxyguanosine-5'-Triphosphate: Enhanced Resolution in M13 Dideoxy Sequencing," Bio. Techniques 4(5):428-432 (1986).
Bashkin et al., "Synthesis and Characterization of Oligonucleotide Peptides," J. Am. Chem. Soc. 56:3168-3176 (1991).
Borchardt and Still, "Synthetic Receptor Binding Elucidated with an Encoded Combinatorial Library," J. Am. Chem. Soc. 116:373-374 (1994).
Brenner and Lerner, "Encoded Combinatorial Chemistry," Proc. Natl. Acad. Sci. USA 89:5381-5383 (1992).
Crick et al., "Codes Without Commas," Proc. Natl. Acad. Sci. USA 43:416-421 (1957).
Cwirla et al., "Peptides on Phage: A Vast Library of Peptides for Identifying Ligands," Proc. Natl. Acad. Sci. USA 87:6378-6382 (1990).
Eritja et al., "Synthesis of Defined Peptide-Oligonucleotide Hybrids Containing a Nuclear Transport Signal Sequence," Tetrahedron 47(24):4113-4120 (1991).
Fodor et al., "Light-Directed, Spatially Addressable Parallel Chemical Synthesis," Science 251:767-773 (1991).
Frank et al., "A New General Approach for the Simultaneous Chemical Synthesis of Large Numbers of Olignucleotides: Segmental Solid Supports," Nuc. Acids. Res. 11(13):4365-4377 (1983).
Frank et al., "Facile and Rapid `Spot-Synthesis` of Large Numbers of Peptides on Membrane Sheets," Peptides 1990 (Giralt and Andreu, eds., ESCOM Science Pub.) pp. 151-152 (1991).
Frank and Doring, "Simultaneous Multiple Peptides Synthesis Under Continuous Flow Conditions on Cellulose Paper Discs as Segmental Solid Supports," Tetrahedron 44:6031-6040 (1988).
Furka et al., "More Peptides by Less Labour," Xth Intl. Symp. Med. Chem. in Budapest, Hungary Abstract No. P-168 (1988).
Furka et al., "Proteins and Nucleic Acids in Three Dimensions," 14th Intl. Congress Biochem. in Prague, Czechoslovakia Abstract No. FR:013 (1988).
Furka et al., "Simultaneous Multiple Peptide Synthesis Under Continuous Flow Conditions on Cellulose Paper Discs as Segmental Solid Supports," Int. J. Peptide Protein Res. 37:487-493 (1991).
Geysen et al., "Use of Peptide Synthesis to Probe Viral Antigens for Epitopes to a Resolution of a Single Amino Acid," Proc. Natl. Acad. Sci. USA 81:3998-4002 (1984).
Geysen et al., "Strategies for Epitope Analysis Using Peptide Synthesis," J. Immunol. Meth. 102:259-274 (1987).
Haralambidis et al., "The Synthesis of Polyamide-Oligonucleotide Conjugate Molecules," Nuc. Acids Res. 18(3):493-505 (1990).
Hayakawa et al., "The Allylic Protection Method in Solid-Phase Oligonucleotide Synthesis: An Efficient Preparation of Solid-Anchored DNA Oligomers," J. Am. Chem. Soc. 112:1691-1696 (1990).
Hodgson, "Receptor Screening and the Search for New Pharmaceuticals," Bio./Tech. 10:973-974 (1992).
Houghton et al., "General Method for the Rapid Solid-Phase Synthesis of Large Numbers of Peptides: Specificity of Antigen-Antibody Interaction at the Level of Individual Amino Acids," Proc. Natl. Acad. Sci. USA 82:5131-5135 (1985).
Houghton et al., "Generation and Use of Synthetic Peptide Combinatorial Libraries for Basic Research and Drug Discovery," Nature 354:84-86 (1991).
Juby et al., "Facile Preparation of 3' Oligonucleotide-Peptide Conjugates," Tetrahedron Letters 32(7):879-882 (1991).
Kaiser et al., "Peptide and Protein Synthesis by Segment Synthesis-Condensation," Science 243:187-192 (1989).
Kerr et al., "Encoded Combinatorial Peptide Libraries Containing Non-Natural Amino Acids," J. Am. Chem. Soc. 115:2529-2531 (1993).
Lam et al., "A New Type of Synthetic Peptide Library for Identifying Ligand-Binding Activity," Nature 354:82-84 (1991).
Lam et al., "Rapid Selection and Structure Determination of Acceptor Binding Ligands from a Large Synthetic Peptide Library," 12th Amer. Pep. Symp. Abstract LW3 (1991).
Needels et al., "Generation and Screening of an Oligonucleotide-Encoded Synthetic Peptide Library," Proc. Natl. Acad. Sci. USA 90:10700-10704 (1993).
Nikolaiev et al., "Peptide-Encoding for Structure Determination of Nonsequencable Polymers Within Libraries Synthesized and Tested on Solid-Phase Supports," Peptide Res. 6(3):161-170 (1993).
Ohlmeyer et al., "Complex Synthetic Chemical Libraries Indexed with Molecular Tags," Proc. Natl. Acad. Sci. USA 90:10922-10926 (1993).
Tjoeng et al., "Multiple Peptide Synthesis Using a Single Support (MPS3)," Int. J. Pept. Protein Res. 35:141-6 (1990).
Van der Zee et al., "Efficient Mapping and Characterization of a T Cell Epitope by the Simultaneous Synthesis of Multiple Peptides," Eur. J. Immunol. 19:43-48 (1989).
Furka et al., 1991, Int. J. Peptides Protein Res. 37:487-493 General method for rapid synthesis of multicomponent peptide mixtures.
Needels et al., 1993, Proc. Natl. Acad. Sci. USA 90: 10700-10704 Generation and screening of an oligonucleotide-encoded synthetic peptide library.
Barrett Ronald W.
Dower William J.
Gallop Mark A.
Needels Michael C.
Affymax Technologies N.V.
Fleisher Mindy
Kaster Kevin
Ketter James
Norviel Vern
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