5'-vinylhalo-aristeromycin/adenosine analogs and immunosuppressa

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 2713, 536 2714, 536 2721, 536 2761, 536 2763, 536 277, 544254, 544256, 544264, 544278, 548260, 5483044, A61K 3170

Type

Patent

Status

active

Patent number

054708370

Description

ABSTRACT:
The present invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of certain 5'-vinylhalo-aristeromycin/adenosine analogs.

REFERENCES:
patent: 3472837 (1969-10-01), Verheyden et al.
patent: 4997924 (1991-03-01), Jarvi et al.
patent: 4997925 (1991-03-01), Jarvi et al.
Jenkins et al., "4'-Substituted Nucleosides. 2. Synthesis of the Nucleoside Antibiotic Nucleocidin," J. Am. Chem. Soc., 98(11), 3347-3357 (1976).
R. S. Root-Bernstein(I), "AIDS Is More Than HIV: Part I," Genetic Engineering News, Sep. 1, 1992, pp. 4-6.
R. S. Root-Bernstein(II), "AIDS Is More Than HIV: Part II," Genetic Engineering News, Sep. 15, 1992, pp. 4-5.
Wolos et al.(I), "Immunomodulation by an Inhibitor of S-Adenosyl-L-Homocysteine Hydrolase: Inhibition of in Vitro and in Vivo Allogeneic Responses," Cellular Immunology, 149, 402-408 (1993).
Wolos et al.(II), "Immunosuppression Mediated by an Inhibitor of S-Adenosyl-L-Homocysteine Hydrolase," J. Immunology, 151(1), 526-534 (1993).
Wolos et al.(III), "Selective Inhibition of T-Cell Activation by and Inhibitor of S-Adenosyl-L-Homocysteine Hydrolase," J. Immunology, 150(8), 3264-3273 (1993).
Wolos et al.(IV), "Suppression of in Vitro and in Vivo T Cell Function by an Inhibitor of S-Adenosyl Homocysteine Hydrolase," Abstract No. 0-427, Keystone Symposia on Molecular & Cellular Biology, 20th Annual Meeting, published in J. Cellular Biochem., Supplement 15E, 1991, Wiley-Liss (publisher), see p. 187.
Schmidt et al., "3-Deazaadenosine-An Inhibitor of Interleukin 1 Production by Human Peripheral Blood Monocytes," Int. J. Immunopharmac., 12(1), 89-97 (1990).
Puck et al., "Regulatory Interactions Governing the Proliferation of T Cell Subsets Stimulated by Pokeweed Mitogen," J. Immunology, 132(3), 1106-1112 (1984).
Hom et al., "The Progression of the Inflammation in Established Collagen-Induced Arthritis Can be Altered by Treatments with Immunological of Pharmacological Agents which Inhibit T Cell Activities," Eur. J. Immunology, 18, 881-888 (1988).
Burmester et al., "T-Cell Regulation and T Cell Clones in Relation to Synovial Inflammation," published in Springer Seminars in Immunopathology, vol. 11, Springer-Verlag publ., 1989, pp. 259-272.
Sinha et al., "Autoimmune Diseases: The Failure of Self Tolerance," Science, 248, 1380-1388 (1990).
Henderson et al., "Mediators of Rheumatoid Arthritis," British Med. Bull., 43(2), 415-428 (1987).
Kyle et al., "Beneficial Effect of Monoclonal Antibody to Interleukin 2 Receptor on Activated T Cells in Rheumatoid Arthritis," Annals Rheumatic Diseases, 48, 428-429 (1989).
McCarthy et al.,(I), "The Synthesis of Unsaturated Adenine Nucleosides Related of Angustmycin A," Chem. Comm., 1967, 536-537.
Palmer et al., "The Mechanism of Action of S-Adenosylhomocysteinase," J. Biol. Chem., 254(4), 1217-1226 (1979).
Chiang et al., "S-Adenosyl-L-homocysteine Hydrolase: Analogues of S-Adenosyl-L-Homocysteine as Potential Inhibitors," Molecular Pharmacology, 13, 939-947 (1977).
Vinegar et al.(I), "Quantitative in vivo Studies of the Acute Actions of Anti-inflammatory Drugs in the Rat," Eur. J. Rheumatol. Inflamm., 1, 204-211 (1978).
Vinegar et al. (II), "Some Quantitave Temporal Characteristics of Carrageenin-Induced Pleurisy in the Rat (37397)," Proc. Soc. Exp. Biol. Med., 143, 711-714 (1973).
Medhi et al., "The Mechanism of Inhibition of S-Adenosyl-L-Homocysteine Hydrolase by Fluorine-Containing Adenosine Analogs," J. Enzyme Inhibitors, 4, 1-13 (1990).
Jarvi et al. (IV), "4',5'-Unsaturated 5'-Halogenated Nucleosides. Mechanism-Based and Competitive inhibitors of S-Adenosyl-L-homocysteine Hydorlase," J. Med. Chem., 34, 647-656 (1991).
McCarthy et al.(II), "4',5'-Unsaturated 5'-Fluoroadenosines Nucleosides: Potent Mechanism Based Inhibitors of S-Adenolyl-L-homocysteine Hydrolase," J. Am. Chem. Soc., 111, 1127-1128 (1989).

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