Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1995-05-30
2000-02-15
Campbell, Eggerton A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435691, 530324, 530326, 530329, C12N 914, C12P 2106, A61K 3800, A61K 3804
Patent
active
06025176&
ABSTRACT:
Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specific to the GAD polypeptides can be used in methods of diagnosis and treatment, including use in immunoadsorptive therapy and the induction of immune tolerance.
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Foster Donald C.
Grubin Catherine E.
Hagopian William
Karlsen Allan E.
Lernmark Ake
Campbell Eggerton A.
Srivastava Devesh
The Board of Regents of the University of Washington and ZymoGen
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