Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1995-01-05

1995-10-24

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540227, C07D50159, A61K 31545

Patent

active

054610443

ABSTRACT:
As new antibacterial agent are provided cephalosporin derivatives having a general formula (I): ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group or a substituted lower alkyl group, R.sup.2 is a hydrogen atom or an ester-forming group easily cleavable by an esterase present in the digestive tracts, R.sup.3 and R.sup.4 may be the same and each is independently a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkenyl group, hydroxyl group, amino group or a lower alkoxy group, and a pharmaceutically acceptable salt thereof.
The cephalosporin derivative of formula (I) is useful as an orally or injectably administrable cephalosporin derivative which exhibits in combination a high antibacterial activity and a favorable characteristic capable of giving a high concentration of this compound in blood when administered.

REFERENCES:
patent: 4812562 (1989-05-01), Watanabe et al.
patent: 4921953 (1990-05-01), Yokoo et al.
patent: 5247073 (1993-09-01), Temansky
Chemical Abstracts vol. 118:233769 (1993).

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