Pentamidine salts useful in the treatment of pneumocystis carini

Details Pentamidine salts useful in the treatment of pneumocystis carini Pentamidine salts useful in the treatment of pneumocystis carini

1989-07-19

1992-01-28

Gray, Bruce

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562587, 562589, A61K 31205

Patent

active

050844806

ABSTRACT:
Salts of pentamidine, formulations containing such salts and the use of such salts of treatment or prophylaxis of pneumocystis carinii. Pentamidine gluconate and lactate has been discovered and found to have high water solubility while providing potentially less toxic alternatives to pentamidine isethionate, especially for aerosolized administration to patients suffering from acquired immunodeficiency syndrome, AIDS, or AIDS related complex, ARC.

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Hawley, Gessner G., The Condensed Chemical Dictionary, Von Nostrand Reinhold Co., New York, 10th Ed., p. 143, (1983).
A Chemotherapeutic Comparison of the Trypanocidal Action of Some Aromatic Diamidine Ashley et al., 1942.
PENTAM.TM. 300 Package Insert, (no date), p. 1206.

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