Indole-5-acetamides for treatment of migraine

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514212, 514323, 514414, 548504, 546204, 540602, A61K 3140, C07D20914

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active

046508104

ABSTRACT:
Compounds are disclosed of general formula (I): ##STR1## wherein R.sub.1, R.sub.3, R.sub.4, R.sub.6 and R.sub.7, which may be the same or different, each represents a hydrogen atom or an alkyl group;

REFERENCES:
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patent: 4252803 (1981-02-01), Webb
Burger, Alfred, Medicinal Chemistry, vol. II, Wiley-Interscience, New York (1970) pp. 1037-1039, 1224-1226.
Espamer, V., "Gramine Derivatives Antagonistic to 5-Hydroxytryptamine," Science 121 (1955) pp. 369-370.
Shaw, et al., "New Agents Inhibitory to the Pressor Effects of Serotonin," Chem. Abst. 50:14127(h) 19.

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