Method of controlling dental caries with streptococcus mutans mu

Details Method of controlling dental caries with streptococcus mutans mu Method of controlling dental caries with streptococcus mutans mu

1978-02-23

1979-01-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 50, A61K 3700, A61K 716

Patent

active

041338758

ABSTRACT:
Mutant strains have been isolated from Streptococcus mutans strain BHT-2(str) which are characterized by a single point mutation in the structural gene for the enzyme, L(+) lactate dehydrogenase, this enzyme being normally responsible for lactic acid production by this bacterium. Streptococcus mutans is believed to be a principal pathogen in dental caries, a disease characterized by the dissolution of the mineral portion of the tooth caused by acid resulting from the interaction of bacteria on the tooth surface with carbohydrates. The mutant strains of the invention will be found useful as prototype nonvirulent effector strains in controlling the incidence and severity of dental caries.

REFERENCES:
klein et al.-Chem. Abst., vol. 83 (1975), p. 41054c.
Freedman et al.-Chem. Abst., vol. 81, (1974), p. 118325k.

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