DNA encoding alanyl tRNA synthetase from streptococcus pneumonin

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...

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435 6, 4353201, 4352523, 43525411, 435325, 536 232, C07H 2104, C12N 900, C12N 1500, C12N 120

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058637770

ABSTRACT:
The invention provides alaS polypeptides and DNA (RNA) encoding alaS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing alaS polypeptides to screen for antibacterial compounds.

REFERENCES:
Guilani et al. (1997) Alanyl-tRNA Synthetase Gene of the Extreme Acidophilic Chemolithoautotrophic Thiobacillus ferroxidans is Highly Homologous to alaS Genes From All Living Kingdoms But Cannot Be Transcribered From Its Promoter in Escherichia coli . Microbiology 143:2179-2187.
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escerichia coli and Bacillus subtilis ", Biochemistry, 5(5) pp. 1681-1690 (1966).
J. Hughes et al., "How Does Pseudomonas Fluorescens , the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) pp. 322-324 (1980).
Putney et al., "Cloning, Partial Sequencing and in Vitro Transcription of the Gene for Alanine tRNA Synthetase," J. Biol. Chem., 256(1) pp. 205-211 (1981).
Chang et al., "Primary Structure of Alanyl-tRNA Synthetase and the Regulation of Its mRNA Levels in Bombyx mori.," J. Biol. Chem., 265(34) pp. 20898-20906 (1990).
Von Der Haar et al., "Target Directed Drug Synthesis: The Aminoacyl-tRNA Synthetases as Possible Targets," Angewandte Chemie, 20(3) pp. 217-223 (1981).
Meinnel et al., "Aminoacyl-tRNA Synthetases: Occurrence, Structure, and Function," In: tRNA: Structure, Biosynthesis, and Function, American Society for Microbiology, pp. 251-292 (1985).

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