Dog-mouse heterohybridoma and gene fragment coding for constant

Details Dog-mouse heterohybridoma and gene fragment coding for constant Dog-mouse heterohybridoma and gene fragment coding for constant

1994-09-15

1997-01-14

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 696, 4351723, 4353201, 536 2353, 536 231, C12N 1500, C07H 2104, C12P 2106, C12P 2104

Patent

active

055938612

ABSTRACT:
A gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine immunoglobulin lambda chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine immunoglobulin kappa chain; a gene fragment which comprises a DNA sequence coding for the constant region of canine immunoglobulin gamma chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-dog chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a canine immunoglobulin; a polypeptide of a mouse-dog chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule cording for an amino acid sequence of the mouse-dog chimeric antibody is incorporated; a dog-mouse heterohybridoma which produces canine immunoglobulin; and a process for preparing a canine immunoglobulin gene.

REFERENCES:
patent: 4842999 (1989-06-01), Fuller et al.
Bio Essays, vol. 8, No. 2, Feb./Mar. 1988, pp. 74-78; M. Verhoeyen et al. ngineering of Antibodies".
Clinical Chemistry, vo. 34, No. 9, 1988, pp. 1668-1675; S. L. Morrison et al. "Production and characterization of genetically engineered antibody molecules".
Wasserman et al Biochemistry 16(14):3161, 1977.
Morrison et al Clin Chem 34(9):1668. 1988.
Fuller et al Fed. Proceedings 44(4): 1329. 1985 (Abst #5369).
Wasserman et al 16(14): 3160, 1977.

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