Phenyl sulfonamide endothelin antagonists

Details Phenyl sulfonamide endothelin antagonists Phenyl sulfonamide endothelin antagonists

1993-10-29

1996-05-07

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548243, 548244, 548245, 548246, C07D26106, A61K 3141

Patent

active

055146961

ABSTRACT:
Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: R.sup.1, R.sup.2 and R.sup.3 are each independently

REFERENCES:
patent: 2888455 (1959-05-01), Kano et al.
patent: 4415496 (1983-11-01), Harris et al.
patent: 4661479 (1987-04-01), Wyvratt, Jr. et al.
patent: 5378715 (1995-01-01), Stein et al.
patent: 5464853 (1995-11-01), Chan et al.
S. Norio et al., Chemical Abstracts, vol. 70, No. 19, (1969), 87639g.
T. Saito, Chemical Abstracts, vol. 73, No. 23, (1970), 120511w.
Derwent Abstract No. 88-289069/41 Feb. 27, 1987.
Derwent Abstract No. 88-195835/28 Nov. 26, 1986.
Derwent Abstract No. 88-061295/09 Jul. 9, 1986.
Derwent Abstract No. 87-152485/22 Octv. 11, 1985.
Derwent Abstract No. 62299 E/30 Dec. 11, 1980.
Derwent Abstract No. 40927 D/23 Sep. 11, 1979.
Derwent Abstract No. 91-254550/35 Feb. 19, 1990.
Derwent Abstract No. 86-246709/38 Nov. 27, 1985.
Derwent Abstract No. 35012 K/15 Sep. 24, 1981.
Allen et al., "Prepartion . . . antagonists", CA116(11):106284Z, p. 778, 1992.
R. D. Desai et al., Chemical Abstracts, vol. 71, No. 11, (1969) 49825c.
R. D. Densai et al., Chemical Abstracts, vol. 71, No. 3, (1969) 12872q.
CA 97:84685r Renal excretion . . . function. Vree et al., p. 23, 1982.
CA 102:197512x PharmacoKinetics . . . dosing, Oie, p. 18; 1985.
CA 108:94444w Nitrile . . . sinomin. Wang et al., p. 651, 1988.
CA 115:35728p Oral . . . formulation. Khanna, p. 415, 1991.
CA 116:106284z Preparation . . . antagonists. Allen et al., p. 778, 1992.
CA 120:18233n The Discovery . . . -1-naphthalenesulfonamide. Stein et al., pp. 21-22, 1994.
CA 120:270370c N-(heteroaryl) . . . antagonists. Murugesan et al., p. 1067, 1994.

Affiliated with

Also associated with

Rating

Phenyl sulfonamide endothelin antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenyl sulfonamide endothelin antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenyl sulfonamide endothelin antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1227534