Human heat shock 27 like protein

Details Human heat shock 27 like protein Human heat shock 27 like protein

1997-07-25

1999-10-05

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4352523, 4352541, 435325, 536235, C12N 100, C12N 510, C12N 1512, C12N 1563, C12P 2102

Patent

active

059622628

ABSTRACT:
The invention provides a new human heat shock 27 like protein, (HSP27P) and polynucleotides which identify and encode HSP27P. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HSP27P.

REFERENCES:
Gaestel et al. Molefular cloning, sequencing and expression in Escherichia coliof the 25-kDa growth related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. Eur. J. Biochem. 179: 209-213, 1989.
Hillier et al. est #WOO821. databases Genbank-est106, EMBL-est54 , accessed May 27, 1998, Apr. 18, 1996.
Hightower, L.E., "Heat Shock, Stress Proteins, Chaperones, and Proteotoxicity", Cell, 66: 191-197 (1991).
Hickey, E. et al., "Sequence and organization of genes encoding the human 27 kDa heat shock protein", Nucleic Acids Res., 14: 4127-4145 (1986).
Miron, T. et al., "A 25-kD Inhibitor of Actin Polymerization Is a Low Molecular Mass Heat Shock Protein", J. Cell Biol., 114: 255-261 (1991).
Marber, M.S. et al., "Overexpression of the Rat Inducible 70-kD Heat Stress Protein in a Transgenic Mouse Increases the Resistance of the Heart to Ischemic Injury", J. Clin. Invest., 95: 1446-1456 (1995).
Simon, M.M. et al., "Heat Shock Protein 70 Overexpression Affects the Response to Ultraviolet Light in Muring Fibroblasts --Evidence for Increased Cell Viability and Suppression of Cytokine Release", J. Clin. Invest., 95: 926-933 (1995).
Udono, H. et al., "Comparison of Tumor-Specific Immunogenicities of Stress-Induced Proteins gp96, hsp90, and hsp70", J. Immunol., 152: 5398-5403 (1994).
Fang, Y. et al., "Hsp90 Regulates Androgen Receptor Hormone Binding Affinity in Vivo", J. Biol. Chem., 271: 28697-28702 (1996).
Young, R.A., "Stress Proteins and Immunology", Annu. Rev. Immunol., 8: 401-420 (1990).
Sargent, C.A. et al., "Human major histocompatibility complex contains genes for the major heat shock protein HSP70", Proc. Natl. Acad. Sci. USA, 86:1968-1972 (1989).
Hendrick, J.P. et al., "Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides",Proc. Natl. Acad. Sci. USA, 90:10216-10220 (1993).
Dix, D.J. et al., "Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility", Proc. Natl. Acad. Sci. USA93: 3264-3268 (1996).
Geiger, B. et al., (Direct Submission), GenBank Sequence Database (Accession 63522), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 63522), Sep. 11,1991.
Geiger, B. et al., (Direct Submission), GenBank Sequence Database (Accession X59541), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 63521), Sep. 11, 1991.
Hickey, E. et al., (Direct Submission, GenBank Sequence Database (Accession 662841), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 662841), Feb. 10, 1995.
Hickey, E. et al., (Direct Submission), GenBank Sequence Database (Accession L39370; X03900), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 662840), Feb. 10, 1995.

Affiliated with

Also associated with

Rating

Human heat shock 27 like protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human heat shock 27 like protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human heat shock 27 like protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1170336