Metal chelating ligands for hypoxic cells

Details Metal chelating ligands for hypoxic cells Metal chelating ligands for hypoxic cells

1992-06-16

1995-02-07

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

436 80, 436 84, 436804, 5483111, 5483275, 5483361, 564209, 564253, 564268, 549555, 568673, C07D23391, A61K 31415

Patent

active

053876920

ABSTRACT:
Agents for the diagnosis or treatment of hypoxic cells comprise a bioreductive moiety such as 2-nitroimidazole, and a metal chelating moiety which is a bis-amine oxime of which a carbon atom adjacent a nitrogen atom is linked to the bioreductive moiety. A chelated metal atom or ion preferably Technetium-99m. The agent diffuses into cells where the 2-nitroimidazole is reduced thus trapping the chelated metal in the cell.

REFERENCES:
patent: 4550175 (1985-10-01), Mixich et al.
patent: 5110826 (1992-05-01), Hori et al.
patent: 5217986 (1993-06-01), Pomponi et al.
Journal of Medicinal Chemistry, 33(9) 2603-2610 (Sep. 1990) Jenkins et al.

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