XIAP IRES and uses thereof

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 435 911, 4353201, 435 701, 536 231, 536 243, 536 2431, 536 2433, A61K 4800, C07H 2102, C07H 2104, C12P 2106, C12N 1500

Patent

active

061597090

ABSTRACT:
The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap-independent translation.

REFERENCES:
patent: 5358856 (1994-10-01), Baltimore et al.
Meerovitch et al., La Autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte Iysate, Journal of Virology, (67):7, pp. 3803, Jul. 1993.
Orkin et al., Report and recommendations of the panel to assess the NIH investment in research on gene therapy, pp. 1-23, Dec. 1995.
W. French Anderson, Human gene therapy, Nature, vol. 392, Supp, pp. 25-30, Apr. 1998.
Belsham, G.J. "Analysis of picornavirus internal ribosome entry site function in vivo", in J.D. Richter (ed.), mRNA Formation and Function, Academic Press, New York, pp. 323-340 (1997).
Deveraux, Q.L. et al., "X-linked IAP is a direct inhibitor of cell-death proteases", Nature, 388:300-4 (1997).
Ehrenfeld, E. "Initiation of translation by picornavirus RNAs", In J.W.B. Hershey, M.B. Matthews and N. Sonenberg (eds.), Translational Control, Cold Spring Harbor Laboratory Press, Cold Spring Harbor Laboratory pp. 549-573 (1996).
Farahani, R. et al., "Genomic organization and primary characterization of miap-3: the murine homologue of human X-linked IAP", Genomics, 42: 514-8 (1997).
Gan, W. et al., "Functional characterization of the internal ribosome entry site of elF4G mRNA", J. Biol. Chem., 273: 5006-12 (1998).
Imataka, H. et al., "A new translational regulator with homology to eukaryotic translation initiation factor 4G", EMBO J., 16:817-25 (1997).
Jackson, R.J. "A comparative view of initiation site selection mechanisms", in J.W.B. Hershey, M.B. Matthews and N. Sonenberg (eds.), Translational Control, Cold Spring Harbor Laboratory Press, Cold Spring Harbor Laboratory pp. 71-112 (1996).
Levy-Strumpf, N. et al. "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death", Mol. Cell. Biol., 17: 1615-25 (1997).
Liston, P. et al., "Genomic characterization of the mouse inhibitor of apoptosis protein-1 and 2 genes", Genomics, 46: 495-503 (1997).
Liston, P. et al. "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes", Nature, 379: 349-353 (1996).
Liston, P. et al. "Life and death decisions: the role of the IAPs in modulating programmed cell death", Apoptosis, 2: 423-441 (1997).
Macejak, D.G. and Sarnow P. "Internal initiation of translation mediated by the 5' leader of a cellular mRNA", Nature, 353: 90-4 (1991).
Nanbu, C. et al. "Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site", J. Biol. Chem., 272: 32061-6 (1997).
Oh, S.K. et al. "Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding", Genes. Dev., 6: 1643-53 (1992).
Pelletier, J. and Sonenberg, N. "Internal Initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA", Nature, 334: 320-5 (1988).
Rothe, M. et al. "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins", Cell, 83: 1243-1252 (1995).
Roy, N. et al. "The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy", Cell, 80:167-178 (1995).
Roy, N. et al. "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases", EMBO J., 16:6914-25 (1997).
Sachs, A.B. et al. "Starting at the beginning, middle, and end: translation initiation in eukaryotes", Cell, 89:831-8 (1997).
Seshagiri, S. and Miller, L. K. "Baculovirus inhibitors of apoptosis (IAPs) block activation of Sf-caspase-1", Proc. Natl. Acad. Sci. USA, 94:13606-11 (1997).
Stein, I. et al. "Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia", Mol. Cell Biol. 18: 3112-9 (1998).
Stoneley, M. et al. "C-Myc 5' untranslated region contains an internal ribosome entry segment", Oncogene, 16:423-8 (1998).
Takahashi, R. et al. "A single BIR domain of XIAP sufficient for inhibiting caspases", J. Biol. Chem., 273: 7787-90 (1998).
Trono, D. et al. "Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region", Science, 241: 445-8 (1988).
Uren, A.G. et al. "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors", Proc. Natl. Acad. Sci USA., 93: 4974-8 (1996).
Vagner, S. et al. "Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes", Mol. Cell Biol., 15:35-44 (1995).
Ye, X., et al. "Ultrabithorax and Antennapedia 5' untranslated regions promote developmentally regulated internal translation initiation", Mol. Cell Biol., 17: 1714-21 (1997).
Farahani et al. Genomic Characterization of MIAP-3: The murine homologue of human X-linked IAP. Genomics vol. 42, No. 3, pp. 514-518 Jun. 1997.
Liston et al. Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes. Genomics, vol. 46, No. 3, pp. 495-503 Dec. 1997.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

XIAP IRES and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with XIAP IRES and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and XIAP IRES and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-215519

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.