PDGF .alpha. receptor

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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435 6, 4352402, 4352551, 530380, 935 13, 935 28, 935 37, C07H 2102, C12Q 168, A61K 3514, C12N 1500

Patent

active

053712056

ABSTRACT:
Isolated DNA molecules that encode a novel PDGF receptor are disclosed. The receptor binds the AA, AB and BB isoforms of PDGF with high affinity. Cells transfected or transformed with the DNA molecules are also disclosed. The cells can be used within methods for detecting PDGF agonist or antagonist activity in a test compound.

REFERENCES:
Yarden et al, Nature, v. 323, 1986, pp. 226-232.
Beggs, Nature, v. 275, 1978, 104-108.
Matsui et al, Science, vol. 243, (1989), pp. 800-804.
Mariatis et al, Molecular Cloning: X Laboratory Manual, Cold Spring Harbor Laboratory (1982) pp. 249-251.
Hart et al, J. Biol. Chem., vol. 262 (1987) pp. 10780-10785.
Heldin et al., "Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types", EMBO J. 7:1387-1393, 1988.
Escobedo et al., "A Common PDGF Receptor Is Activated by Homodimeric A and B Forms of PDGF", Science 240:1532-1534, 1988.
Claesson-Welsh et al., J. Biol. Chem. 264:1742-1747, 1989.
Claesson-Welsh et al., Proc. Natl. Acad. Sci. USA 86:4917-4921, 1989.
Hart et al., Growth Factors and Their Receptors: Genetic Control and Rational Application, Alan R. Liss, Inc., 1989, pp. 297-305.
Gronwald et al., Proc. Natl. Acad. Sci. USA 85:3435-3439, 1988.
Hart et al., Science 240:1529-1531, 1988.
Daniel et al., Proc Natl. Acad. Sci. USA 82:2684-2687, 1985.
Claesson-Welsh et al., Mol. Cell. Biol. 8:3476-3486, 1988.

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