Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-06-28
2005-06-28
Woitach, Joseph (Department: 1632)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023400, C536S023500, C536S024100, C514S04400A, C435S320100
Reexamination Certificate
active
06911537
ABSTRACT:
A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcription from response elements present in steroid-inducible cytochrome P450 genes in response to hundreds of natural and synthetic compounds with biological activity, including therapeutic steroids as well as dietary steroids and lipids. Instead of hundreds of receptors, one for each inducing compound, the invention SXR receptors monitor aggregate levels of inducers to trigger production of metabolizing enzymes in a coordinated metabolic pathway. Agonists and antagonists of SXR are administered to subjects to achieve a variety of therapeutic goals dependent upon modulating metabolism of one or more endogenous steroids or xenobiotics to establish homeostasis. An assay is provided for identifying steroid drugs that are likely to cause drug interaction if administered to a subject in therapeutic amounts. Transgenic animals are also provided which express human SXR, thereby serving as useful models for human response to various agents which potentially impact P450-dependent metabolic processes. Also provided are expression systems and expression vectors having SXR receptors and the like operably linked to target genes of interest.
REFERENCES:
Beato et al. Cell 83:851-857, 1995.
Mangelsdorf et al. Cell 83:841-850, 1995.
Evans Science 240:889-895, 1988.
Foley & Lardner
Reiter Stephen E.
The Salk Institute for Biological Studies
Woitach Joseph
LandOfFree
Xenobiotic compound modulated expression systems and uses... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Xenobiotic compound modulated expression systems and uses..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Xenobiotic compound modulated expression systems and uses... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3517494