Xanthocillin X monomethyl ether derivative and antitumor agent c

Details Xanthocillin X monomethyl ether derivative and antitumor agent c Xanthocillin X monomethyl ether derivative and antitumor agent c

1990-05-18

1993-05-11

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

558302, A61K 31275, C07C26506

Patent

active

052100979

ABSTRACT:
A xanthocillin X monomethyl ether derivative represented by the formula (I) ##STR1## wherein R represents an alkyl group, an alkenyl group, an alkoxycarbonyl group, an aralkyl group, an alkyl group substituted with a pyridyl group or a halogen atom, an aralkyl group substituted with an alkyl group or a halogen atom, or an aroyl group, which exerts an intense effect of inhibiting the proliferation of a tumor, in particular, a solid tumor.

REFERENCES:
Devita et al. Cancer, Principles and Practice of Oncology 144-145.
Riggs Principles of Cancer Chemotherapy.
The Journal of Antibiotics, vol. 34, No. 12, Dec. 1981, pp. 1556-1661.
The Journal of Antibiotics, vol. 21, No. 10, Oct. 1968, pp. 582-586.
Chemical Abstracts, vol. 68, No. 13, Abstract 57611h, p. 5562, Mar. 25, 1968, (Hans).
Takatsuki et al CA 70-56257b.

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