Xanthine derivates, their preparation and their use in...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S271000

Reexamination Certificate

active

07838529

ABSTRACT:
Compounds of formula (I)wherein R1is a phenylcarbonylmethyl group wherein the phenyl moiety is substituted by R10and R11and R2to R4and R10and R1lare defined as in the claims, or the prodrugs or salts thereof, particularly the physiologically acceptable salts thereof, pharmaceutical compositions containing these compounds, and methods of treating type II diabetes mellitus and obesity using these compounds.

REFERENCES:
patent: 2928833 (1960-03-01), Leake et al.
patent: 4005208 (1977-01-01), Bender
patent: 4599338 (1986-07-01), Regnier et al.
patent: 5041448 (1991-08-01), Janssens
patent: 5051517 (1991-09-01), Findeisen
patent: 5223499 (1993-06-01), Greenlee
patent: 5234897 (1993-08-01), Findeisen et al.
patent: 5258380 (1993-11-01), Janssens
patent: 5266555 (1993-11-01), Findeisen et al.
patent: 5389642 (1995-02-01), Dorsch
patent: 5470579 (1995-11-01), Bonte et al.
patent: 5719279 (1998-02-01), Kuefner-Muhl et al.
patent: 5753635 (1998-05-01), Buckman
patent: 6303661 (2001-10-01), Demuth
patent: 6342601 (2002-01-01), Bantick
patent: 6548481 (2003-04-01), Demuth et al.
patent: 6579868 (2003-06-01), Asano
patent: 6784195 (2004-08-01), Hale et al.
patent: 6821978 (2004-11-01), Chackalamannil
patent: 6869947 (2005-03-01), Kanstrup
patent: 7060722 (2006-06-01), Kitajima
patent: 7074794 (2006-07-01), Kitajima
patent: 7074798 (2006-07-01), Yoshikawa
patent: 7074923 (2006-07-01), Dahanukar
patent: 7109192 (2006-09-01), Hauel
patent: 7179809 (2007-02-01), Eckhardt
patent: 7183280 (2007-02-01), Himmelsbach
patent: 7192952 (2007-03-01), Kanstrup
patent: 7217711 (2007-05-01), Eckhardt
patent: 7235538 (2007-06-01), Kanstrup et al.
patent: 7407955 (2008-08-01), Himmelsbach et al.
patent: 7495005 (2009-02-01), Himmelsbach et al.
patent: 2002/0161001 (2002-10-01), Kanstrup
patent: 2002/0169174 (2002-11-01), Chackalamannil et al.
patent: 2002/0198205 (2002-12-01), Himmelsbach
patent: 2003/0105077 (2003-06-01), Kanstrup et al.
patent: 2003/0199528 (2003-10-01), Kanstrup
patent: 2003/0232987 (2003-12-01), Dahanukar et al.
patent: 2003/0236272 (2003-12-01), Carr
patent: 2004/0034014 (2004-02-01), Kanstrup et al.
patent: 2004/0077645 (2004-04-01), Himmelsbach et al.
patent: 2004/0082570 (2004-04-01), Yoshikawa
patent: 2004/0087587 (2004-05-01), Himmelsbach
patent: 2004/0097510 (2004-05-01), Himmelsbach et al.
patent: 2004/0116328 (2004-06-01), Yoshikawa et al.
patent: 2004/0122228 (2004-06-01), Maier
patent: 2004/0138214 (2004-07-01), Himmelsbach et al.
patent: 2004/0138215 (2004-07-01), Eckhardt
patent: 2004/0166125 (2004-08-01), Himmelsbach
patent: 2005/0020574 (2005-01-01), Hauel et al.
patent: 2005/0026921 (2005-02-01), Eckhardt
patent: 2005/0130985 (2005-06-01), Himmelsbach
patent: 2005/0171093 (2005-08-01), Eckhardt et al.
patent: 2005/0187227 (2005-08-01), Himmelsbach et al.
patent: 2005/0203095 (2005-09-01), Eckhardt
patent: 2005/0234108 (2005-10-01), Himmelsbach et al.
patent: 2005/0261352 (2005-11-01), Eckhardt
patent: 2006/0004074 (2006-01-01), Eckhardt
patent: 2006/0063787 (2006-03-01), Yoshikawa
patent: 2006/0079541 (2006-04-01), Langkopf
patent: 2006/0094722 (2006-05-01), Yasuda
patent: 2006/0142310 (2006-06-01), Pfrengle et al.
patent: 2006/0173056 (2006-08-01), Kitajima
patent: 2006/0205711 (2006-09-01), Himmelsbach
patent: 2006/0247226 (2006-11-01), Himmelsbach
patent: 2007/0027168 (2007-02-01), Pfrengle et al.
patent: 2007/0088038 (2007-04-01), Eckhardt
patent: 2007/0093659 (2007-04-01), Bonfanti
patent: 2007/0142383 (2007-06-01), Eckhardt
patent: 2007/0185091 (2007-08-01), Himmelsbach et al.
patent: 2007/0219178 (2007-09-01), Muramoto
patent: 2007/0259900 (2007-11-01), Sieger
patent: 2007/0281940 (2007-12-01), Dugi
patent: 2008/0107731 (2008-05-01), Kohlrausch
patent: 2010/0168122 (2010-07-01), Hatley et al.
patent: 2136288 (1995-05-01), None
patent: 2418656 (2002-02-01), None
patent: 2496325 (2004-03-01), None
patent: 2496249 (2004-04-01), None
patent: 2505389 (2004-05-01), None
patent: 2508233 (2004-06-01), None
patent: 2529729 (2004-12-01), None
patent: 2543074 (2005-06-01), None
patent: 2555050 (2005-09-01), None
patent: 2556064 (2005-09-01), None
patent: 2590912 (2006-06-01), None
patent: 10109021 (2002-09-01), None
patent: 10117803 (2002-10-01), None
patent: 0149578 (1985-07-01), None
patent: 0400974 (1990-05-01), None
patent: 0399285 (1990-11-01), None
patent: 0412358 (1991-02-01), None
patent: 0524482 (1993-01-01), None
patent: 0657454 (1995-06-01), None
patent: 1054012 (2000-11-01), None
patent: 1338595 (2003-08-01), None
patent: 1514552 (2005-03-01), None
patent: 1537880 (2005-08-01), None
patent: 385302 (1973-04-01), None
patent: 2707641 (1995-01-01), None
patent: S37-4895 (1962-06-01), None
patent: 2003/300977 (2003-10-01), None
patent: 2006/045156 (2006-02-01), None
patent: 91/07945 (1991-06-01), None
patent: 94/03456 (1994-02-01), None
patent: 99/29695 (1999-06-01), None
patent: 02/02560 (2002-01-01), None
patent: 02/14271 (2002-02-01), None
patent: 02/24698 (2002-03-01), None
patent: 02/068420 (2002-09-01), None
patent: 03/004496 (2003-01-01), None
patent: 03/024965 (2003-03-01), None
patent: 03/057200 (2003-07-01), None
patent: 03/104229 (2003-12-01), None
patent: 2004/018467 (2004-03-01), None
patent: 2004/018468 (2004-03-01), None
patent: 2004/028524 (2004-04-01), None
patent: 2004/033455 (2004-04-01), None
patent: 2004/041820 (2004-05-01), None
patent: 2004/046148 (2004-06-01), None
patent: 2004/048379 (2004-06-01), None
patent: 2004/050658 (2004-06-01), None
patent: 2004/096806 (2004-11-01), None
patent: 2004/108730 (2004-12-01), None
patent: 2004/111051 (2004-12-01), None
patent: 2005/058901 (2005-06-01), None
patent: 2005/082906 (2005-09-01), None
patent: 2005/085246 (2005-09-01), None
patent: 2006/029769 (2006-03-01), None
patent: 2006/048427 (2006-05-01), None
patent: 2006/068163 (2006-06-01), None
patent: 2007/017423 (2007-02-01), None
“Concise Encyclopedia Chemistry” (1994) p. 524.
Augustyns, K. et al., The Unique Properties of Dipeptidyl-peptidase IV (DPP IV/CD 26) and the Therapeutic Potential of DPP-IV Inhibitors, Current Medicinal Chemistry, vol. 6, No. 4, 1999, pp. 311-327.
Beljean-Leymarie et al., Hydrazines et hydrazones hétérocycliques. IV. Synthèses de dérivés de l'hydrazine dans la série des imidazo[4,5-d]pyridazinones-4, Can. J. Chem., vol. 61, No. 11, 1983, pp. 2563-2566.
Bollag, R.J. et al; “Osteoblast-Derived Cells Express Functional Glucose-Dependent Insulinotropic Peptide Receptors,” Endocrinology, vol. 141, No. 3, 2000, pp. 1228-1235.
Brittain, H.G., “Methods for the Characterization of Polymorphs: X-Ray Powder Diffraction,” Polymorphism in Pharmaceutical Solids, 1999, p. 235-238.
Busso et al., “Circulating CD26 is Negatively Associated with Inflammation in Human and Experimental Arthritis,” Am. J. Path., vol. 166, No. 2, Feb. 2005, pp. 433-442.
Caira, M.R., “Crystalline polymorphism of organic compounds” Topics in Current Chemistry, Springer, Berlin, vol. 198, 1998, p. 163-208.
Conarello, S.L. et al; “Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance,” PNAS 2003; 100:6825-6830; originally published online May 14, 2003; information current as of Dec. 2006. www.pnas.org/cgi/content/full/100/11/6825.
Cygankiewicz, Andrzej et al., Investigations into the Piperazine Derivatives of Dimethylxanthine:, ACTA POLON. PHARM. [Papers of Polish Pharmacology], XXXOV, No. 5, pp. 607-612, 1977.
Deacon, C.F. et al; “Dipeptidyl peptidase IV inhabitation as an approach to the treatment and prevention of type 2 diabetes: a historical perspective;” Biochemical and Biophysical Research Communications (BBRC) 294 (2002) 1-4.
DeMeester, I. et al.; “CD26, let it cut or cut it down”, Review: Immunology Today; Aug. 1999, vol. 20, No. 8 pp. 367-375.
Korom, S. et al; Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients1,2, Transplantation, May 27, 1997, vol. 63, No. 10, pp. 1495-1500.
Januvia; Patient Information; Oct. 2007.
Pa

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