Xanthenylamide handle for use in peptide synthesis

Details Xanthenylamide handle for use in peptide synthesis Xanthenylamide handle for use in peptide synthesis

1992-05-15

1994-04-26

Kight, III, John

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

525132, 526 72, 5483644, 5483711, 549394, B32B 516, C08F 800, C08F 200, C07D23100

Patent

active

053065620

ABSTRACT:
The preparation and properties of xanthenylamide handles for use in peptide synthesis is disclosed. The compounds, omega-(9-(9-fluorenylmethyloxycarbonyl)aminoxanthan-2-oxy)alkanoic acid derivatives, are used as peptide handles in the solid-phase synthesis of peptide amides.

REFERENCES:
Albericio, F. et al., J. Organ. Chem. 55:3730-3743 (1990).
P. Sieber, Tetrahedron Letters 28:2107-2110 (1987).
Barany et al., Int. J. Peptide Protein Res. 30:703-739 (1987).
Caciagli, V. et al., Proceeding of the European Peptide Symposium (Sep. 1990), Abstract P97.
European Search Report for EP 91307876.2.
Patrick et al., Chemical Abstracts 79:78525a (Oct. 1, 1973).
Capuano et al., Chemical Abstracts 76:85648j (Apr. 10, 1972).
Bender et al., Chemical Abstracts 99:88276A (Sep. 5, 1983).

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