β-Lactamyl vasopressin V 1a Antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S363000, C540S364000

Reexamination Certificate

active

07119083

ABSTRACT:
Novel 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives and 2-(azetidin-2-on-1-yl)alkoxyalkanoic acid derivatives are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1areceptor.

REFERENCES:
patent: 5759865 (1998-06-01), Bruns et al.
patent: 6204260 (2001-03-01), Bruns, Jr. et al.
patent: 6627625 (2003-09-01), Koppel
patent: WO 97/30707 (1997-08-01), None
Hirai et al, “An Example of the β-Lactam Ring Formation and Novel Pyrrolinoazetidinone Ring Construction”,Sankyo Kenyusho Nempo, vol. 37, pp. 133-139, (1985).
Ojima et al., “Asymmetric Alkylations of a Phenylalanylglycinate Equivalent. New routes to Dipeptides BEaring α-Alkyl-α-amino Acid Residues”,J. Amer. Chem. Soc., vol. 122, pp. 770-774, (1990).

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