β-benzyloxyaspartate derivatives with amino group on...

Details β-benzyloxyaspartate derivatives with amino group on... β-benzyloxyaspartate derivatives with amino group on...

2007-07-24

2007-07-24

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S547000, C514S561000, C514S567000, C560S088000, C560S196000, C562S444000, C562S568000

Reexamination Certificate

active

10481237

ABSTRACT:
L-threo-β-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1):wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl portion optionally substituted, an alicyclic acyl group, an aromatic acyl group with a substituent on the aromatic ring, an amino acid-derived group or a biotin derivative-derived group,having an amino substituent on the benzene ring, and salts thereof, which can easily bind to affinity column chromatography carriers as ligands of glutamate transporter proteins.

REFERENCES:
patent: 6147113 (2000-11-01), Shimamoto et al.
patent: 0658539 (1995-06-01), None
patent: 0844234 (1998-05-01), None
DL-threo-B-Benzyloxyaspartate, A Potent Blocker of Excitatory amino acid transporters, Molecular Pharmacology, 1998, vol. 53(2), pp. 195-201, especially p. 197.
Shimamoto, et al., Mol. Pharm., vol. 53, pp. 195-201, especially p. 195 (1998).
Arriza J.L. et al. “Functional Comparisons of Three Glutamate Transporter Subtypes Cloned From Human Motor-Cortex” J. of Neuroscience, vol. 14, No. 9, Sep. 1, 1994.
Lebrun B. et al. “New Beta-Hydroxyasparate Derivatives . . . Glutamate/Asparate Transporter” J. of Biological Chemistry, vol. 272, No. 33, Aug. 15, 1997, pp. 20336-20339.

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