α-galactosidases and methods for making and using them

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S208000, C435S320100, C435S069100, C435S252300, C435S018000, C536S023200, C530S350000

Reexamination Certificate

active

06949369

ABSTRACT:
The invention relates to α-galactosidase and to polynucleotides encoding the α-galactosidase. In addition methods of designing new α-galactosidases and method of use thereof are also provided. The α-galactosidases have increased activity and stability at increased pH and temperature.

REFERENCES:
patent: 5686294 (1997-11-01), Sogabe et al.
patent: 5958751 (1999-09-01), Murphy et al.
patent: 6057098 (2000-05-01), Buechler et al.
patent: 0 606 008 (1994-07-01), None
patent: 0 687 732 (1995-12-01), None
Witkowski et al. , Biochemistry 38:11643-11650, 1999.
Bork , Genome Research, 10:348-400, 2000.
Van de Loo et al. , Proc. Natl. Acad. Sci. 92:6743-6747, 1995.
Broun et al. , Science 282:1315-1317, 1998.
Verhees et al. , EMBL accession number AF195244, Nov. 1, 2000.
Sakka, et al., “Nucleotide Sequence of theClostridium Stercorarium xynAGene Encoding Xylanase A: Identification of Catalytic and Cellulose Binding Domains”,Biosci. Biotech. Biochem, vol. 57, No. 2, pp. 273-277, 1993.
Keller, et al., “Thermococcus alcaphiliussp. nov., a new hyperthermophilic archaeum growing on polysulfide at alkaline pH”,Arch. Microbiol., vol. 164, pp. 390-395, 1995.
Seffernick, et al., “Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identifical but Funtionally Different”,Journal of Bacteriology, vol. 183, No. 8, pp. 2405-2410, Apr., 2001.
Dakhova, e al., “Cloning and Expression inEscherichia coliofThermotoga neapolitanaGenes Coding for Enzymes of Carobhydrate Substrate Degradation”,Biochemical and Biophysical Research Communicationsvol. 194, No. 3, pp. 1359-1364, Aug. 16, 1993.
Canganella, et al., “Characterization of amylolytic and pullulytic enzymes fromthermophilic archaeaand from a newFervidobacteriumspecies”,Appl. Microbiol. Biotechnol., vol. 42, pp. 239-245, 1994.
GenBank Database Record NID g3236129 :Pyrococcus horikoshiiOT3 genomic DNA, 27001-54400 nt. Position, Submitted by Tanaka et al., Jul. 25, 1998.
Kawarabayasi, et al., GenEMBL Accession No. AP00002, Apr. 2000.
Kawarabayasi, et al., PIR Accession No. E71144, Aug. 14, 1998.
Abaza, et al., “Effects of Amino Acid Substitutions Outside an Antigenic Site on Protein Binding to Monoclonal Antibodies of Predetermined Specificity Obtained by Peptide Immunization: Demonstration with Region 94-100 (Antigenic Site 3) of Myoglobin”,Journal of Protein Chemistry, vol. 11, No. 5, pp. 433-444, 1992.
Ngo, et al., “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox”,The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14, pp. 491-494, 1994.
Campbell, “General Properties and Applications of monoclonal antibodies”,Elsevier Science Publishers, section 1.1., pp. 1-32, 1984.
Li, et al., “β-endorphin omission analogs: Dissociation of immunoreactivity from other biological activities”,Proc. Natl. Acad. Sci., vol. 77, No. 6, pp. 3211-3214, Jun., 1980.
Lederman, et al., A Single Amino Acid Substitution in a Common African Allele of the CD4 Molecule Ablates Binding of the Monoclonal Antibody, OKT4,Mol. Immunology, vol. 28, No. 11, pp. 1171-1181, 1991.
Colman, “Effects of amino acid sequence changes on antibody-antigen interactions”,Research in Immunology, vol. 145, No. 1, pp. 33-36, 1994.
Koizumi, et al., “Isolation and characterization of novel heterogenous branched cyclomalto-oligosaccharides (cyclodextrins) produced by transgalactosylation with a-galactosidasse from coffee bean”,Carbohydrate Research, vol. 278, pp. 129-142, 1995.
Ishii, et al., “Human α-galactosidase gene expression: significance of two peptide regions encoded by exons 1-2 and 6”,Biochimica et Biophysica Acta, vol. 1204, pp. 365-270, 1994.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

α-galactosidases and methods for making and using them does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with α-galactosidases and methods for making and using them, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and α-galactosidases and methods for making and using them will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3395174

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.