α-form or β-form crystal of acetanilide derivative

Details α-form or β-form crystal of acetanilide derivative α-form or β-form crystal of acetanilide derivative

2008-03-11

2008-03-11

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10494018

ABSTRACT:
To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with α-form crystal and β-form crystal of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenyleth-yl)amino]ethyl]acetanilide. The α-form crystal does not exhibit hygroscopicity and has stability such that it can be used as a medicine, and is useful for mass synthesis in the industrial production. The β-form crystal does not relatively exhibit hygroscopicity and is also useful as a production intermediate of the α-form crystal.

REFERENCES:
patent: 6346532 (2002-02-01), Maruyama et al.
patent: 6627642 (2003-09-01), Kimura et al.
patent: 6706733 (2004-03-01), Kimura et al.
patent: 466952 (1992-01-01), None
patent: 11-255649 (1999-09-01), None
patent: 2000-212168 (2000-08-01), None
patent: WO-99/20607 (1999-04-01), None
Rouhi, Chemical and Engineering News, Feb. 24, 2003, pp. 32-35, especially p. 32.
International Search Report for PCT/JP02/11217, Jan. 28, 2003.

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