α2B and α2C agonists

Details α2B and α2C agonists α2B and α2C agonists

2009-05-01

2011-12-20

Sznaidman, Marcos (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S233000

Reexamination Certificate

active

08080570

ABSTRACT:
Described herein are compounds that can be useful as bioactive agents. More specifically, the compounds described herein can be useful as both α2Band α2Cadrenergic agonists. Methods of synthesis and administration of the compounds are also disclosed.

REFERENCES:
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patent: WO 03/075922 (2003-09-01), None
Kowal, Dianne; et al.: Functional Calcium Coupling with the Human Metabotropic Glutamate Receptor Subtypes 2 and 4 by Stable Co-Expression with a Calcium Pathway Facilitating G-Protein Chimera in Chinese Hamster Ovary Cells. Biochemical Pharmacology 66, 2003, pp. 785-790.
Serrano, M.I.; et al.: Synthesis and Analgesic Activity of 2-Am ino-5-tert-butyl-2-oxazoline, Arzneimittel-Forschung, 45(1), 22-6 Coden: Arznad.
Silverman, Richard B.: prodrugs and Drug Delivery Systems, Organic Chemistry of Drug Design and Drug Action, 2d Ed., Elsevier Academic Press: Amsterdam, 2004, pp. 496-557.
Ueda, Shigeo; et al.: 4,5-Disubstituted-1,3-oxazolidin-2-imine Derivatives: a New Class of Orally Bioavailable Nitric Oxide Synthase Inhibitor, Bioorganic & Medicinal Chemistry Letters 14(2004) 313-316.

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