α2B and α2C agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S233000

Reexamination Certificate

active

08080570

ABSTRACT:
Described herein are compounds that can be useful as bioactive agents. More specifically, the compounds described herein can be useful as both α2Band α2Cadrenergic agonists. Methods of synthesis and administration of the compounds are also disclosed.

REFERENCES:
patent: WO 92/00073 (1993-01-01), None
patent: WO 03/075922 (2003-09-01), None
Kowal, Dianne; et al.: Functional Calcium Coupling with the Human Metabotropic Glutamate Receptor Subtypes 2 and 4 by Stable Co-Expression with a Calcium Pathway Facilitating G-Protein Chimera in Chinese Hamster Ovary Cells. Biochemical Pharmacology 66, 2003, pp. 785-790.
Serrano, M.I.; et al.: Synthesis and Analgesic Activity of 2-Am ino-5-tert-butyl-2-oxazoline, Arzneimittel-Forschung, 45(1), 22-6 Coden: Arznad.
Silverman, Richard B.: prodrugs and Drug Delivery Systems, Organic Chemistry of Drug Design and Drug Action, 2d Ed., Elsevier Academic Press: Amsterdam, 2004, pp. 496-557.
Ueda, Shigeo; et al.: 4,5-Disubstituted-1,3-oxazolidin-2-imine Derivatives: a New Class of Orally Bioavailable Nitric Oxide Synthase Inhibitor, Bioorganic & Medicinal Chemistry Letters 14(2004) 313-316.

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