Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-07-25
2006-07-25
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S276000
Reexamination Certificate
active
07081475
ABSTRACT:
Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well as tumor formation in a subject are described herein.
REFERENCES:
patent: 6703414 (2004-03-01), Powis et al.
patent: 2302021 (1997-01-01), None
patent: WO 03/024183 (2003-03-01), None
Helveita Chimica Acta—vol. 58, Fasc. 6 (1975)—Nr. 179-180, “Selektive Funktionalisierung von Wortmannin mit Hilfe einer Furanring-Maskierung”, von Walkter Haefliger, Zoltan Kis und Daniel Hauser, Sandoz AG, Pharma Department, Chemische Forschung, CH-4002 Basel, pp. 1620-1628.
Norman, Bryan H. et al.,Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs, J. Med. Chem., 1996, 39:1106-1111.
Peter Wipf
Powis Garth
Anderson Rebecca
Arizona Board of Regents, Acting on behalf of the University of
Pepper Hamilton LLP
Prolx Pharmaceuticals Corp.
Saeed Kamal A.
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