Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Reexamination Certificate
2008-06-02
2011-11-29
Gonzalez, Porfirio Nazario (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
C514S502000
Reexamination Certificate
active
08067628
ABSTRACT:
The present invention relates to water-soluble binuclear cationic nitrosyl iron complexes with natural aliphatic thiolyls of general formula [Fe2(SR)2(NO)4]SO4,wherein R is sulfur-containing aliphatic ligands of natural origin, preferably, cystamine or penicillamine, to a method for the preparation thereof, to use thereof as an anticancer agent, to an apoptosis inducer, to a pharmaceutical composition comprising said complexes in an effective amount, and to a kit useful for the treatment of cancer diseases.
REFERENCES:
Dillinger et al., Dalton Transactions, pp. 3562-3571 (2007).
Janczyk et al., Nitric Oxide, vol. 10, No. 1, pp. 42-50 (2004).
Aldoshin Sergei Mikhailovich
Emelianova Nina Sergeevna
Lysenko Konstantin Alexandrovich
Rudneva Tatyana Nikolaevna
Sanina Natalia Alexeevna
Gonzalez Porfirio Nazario
Institute of Problems of Chemcial Physics RAS (IPCP RAS)
Osha • Liang LLP
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