Variously substituted derivatives of guanidine, and their...

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C514S415000, C514S634000, C548S483000

Reexamination Certificate

active

07368605

ABSTRACT:
Formula (I) compoundsare described where the groups are as identified in the text, and their use as medicines, particularly as anti-diabetes, serum glucose-lowering and anti-obesity agents. They are useful for the prophylaxis and treatment of diabetes, particularly type 2 diabetes, and its complications, syndrome X, the various forms of insulin resistance, and hyperlipidaemias, as well as for the treatment of obesity.

REFERENCES:
patent: 4731383 (1988-03-01), Erczi et al.
patent: 93/03714 (1993-03-01), None
patent: WO 97/23203 (1997-07-01), None
International Search Report for PCT/IT03/00792 dated Apr. 26, 2004.
Wilkinson-Berka, et al.,ALT-946 and Aminoguanidine, Inhibitors of Advanced Glycation, Improve Severe Nephropathy in the Diabetic Transgenic(mREN-2)27 Rat, Diabetes, vol. 51, Nov. 2002, XP-002276482, pp. 3283-3289.

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