Various 1,5,10,11-tetrahydrobenzo [4,5]-cyclohepta [1,2-b]pyrazo

Details Various 1,5,10,11-tetrahydrobenzo [4,5]-cyclohepta [1,2-b]pyrazo Various 1,5,10,11-tetrahydrobenzo [4,5]-cyclohepta [1,2-b]pyrazo

1976-06-23

1977-07-05

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424256, 424267, 260240TC, 260296P, C07D47104

Patent

active

040339700

ABSTRACT:
Compounds of the formulas wherein R.sub.1 is lower alkyl, phenyl, benzyl or phenethyl; R.sub.2 is hydrogen, lower alkyl or phenyl; R is ##STR1## N IS AN INTEGER FROM 3 TO 6; R.sub.3 and R.sub.4 are each lower alkyl or R.sub.3 and R.sub.4 taken together with the N-atom form a heterocyclic ring of the formula ##STR2## wherein R.sub.5 is hydrogen, lower alkyl, or lower alkoxy; and pharmaceutically acceptable acid addition salts thereof are disclosed. These compounds and their salts possess central nervous system activity and are useful as anti-anxiety agents.

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