Cardioplegic compositions

Details Cardioplegic compositions Cardioplegic compositions

1992-02-18

1994-03-01

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514832, 514833, 435 1, 435 2, 128897, 128898, 604 49, 604 50, 604 51, 604 52, 424679, A61K 3170, A61K 31715, A61K 3314

Patent

active

052907660

ABSTRACT:
An aqueous cardioplegic solution providing significantly improved cardiac function after a period of exposure to cardioplegia, contains NaCl in the range of 70-110 mM; KCl in the range of 10-16 mM; CaCl.sub.2 in the range of 0.5-1.0 mM; MgCl.sub.2 in the range of 8-16 mM; NaHCO.sub.3 in the range of 10-20 mM; D-Glucose in the range of 5-15 mM; L-Aspartic acid in the range of 5-20 mM; and Lactobionic acid in the range of 0-15 mM.

REFERENCES:
patent: 3928574 (1975-12-01), Phillips
patent: 4415556 (1983-11-01), Bretschneider
patent: 4605644 (1986-08-01), Foker
patent: 4719201 (1988-01-01), Foker
patent: 4923442 (1990-05-01), Segall et al.
patent: 4938961 (1990-07-01), Collins et al.
patent: 4988515 (1991-01-01), Buckberg
patent: 5082831 (1992-01-01), Leaf et al.
"L-Aspartate Improves the Functional Recovery of Explanted Hearts Stores in St. Thomas' Hospital Cardioplegic Solution at 4.degree. C.", The Journal of Thoracic and Cardiovascular Surgery, vol. 99, No. 3, pp. 510-517, Mar. 1990 by The C. V. Mosby Company Y. S. Choong, PhD, and J. B. Gavin, DDS, PhD.

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