Variants of protein kinases

Details Variants of protein kinases Variants of protein kinases

2005-08-30

2005-08-30

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C530S350000, C424S094600

Reexamination Certificate

active

06936450

ABSTRACT:
The present invention concerns nucleic acid sequences and amino acid sequences of dominant negative variants of kinases, i.e. of sequences which inhibit activity of kinases in a dominant manner. The invention also concerns pharmaceutical compositions and detection methods using these sequences.

REFERENCES:
patent: WO 98/55507 (1998-12-01), None
patent: WO 99/40102 (1999-08-01), None
Inohara et al Rick, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J Biol Chem. May 15, 1998;273(20):12296-300.
Gelfand et al. (1999) “ASDB: database of alternatively spliced genes” Nucl. Acids Res. 27:301-2.
Smith et al. (1989) “Alternative splicing in the control of gene expression” Annu. Rev. Genet. 23:527-77.
Breibart et al. (1987) “Alternative Splicing: A ubiquitous mechanism for the generation of multiple protein isoforms from single genes” Ann. Rev. Biochem. 56:467-495.
Chabot (1996) “Directing alternative splicing cast and scenarios” Trends Genet. 12:472-8.
Stamm et al. (1994) “A sequence compilation and comparison of exons that are alternatively spliced in neurons” Nucl. Acids Res. 22:1515-26.
Sharp (1994) “Split genes and RNA splicing” Cell 77:805-15.
Takehito Ueyama et al.; Biochemical and Biophysical Research Communications; vol. 269, pp. 557-563 (2000).
Richard Ross; Growth Hormone & IGF Research, vol. 9; pp. 42-46; 1999.

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