Variants of corticotropin releasing hormone receptor Type 1...

Details Variants of corticotropin releasing hormone receptor Type 1... Variants of corticotropin releasing hormone receptor Type 1...

2006-07-04

2006-07-04

Kemmerer, Elizabeth (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C530S306000

Reexamination Certificate

active

07071161

ABSTRACT:
The present invention identifies four new isoforms of human corticotropin releasing hormone receptor type 1 (CRH-R1e, 1f, 1g and 1h) and three new isoforms of mouse corticotropin releasing hormone receptor type 1 (mCRH-R1c, 1e and 1f). The data indicate that polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, external stress (UV), and that cAMP dependent pathways and TPA may regulate CRH-R1.

REFERENCES:
patent: 6638905 (2003-10-01), Perrin et al.
Liaw et al., Localization of ligand-binding domains of human corticotropin-releasing factor receptor: A chimeric receptor approach, Mol. Endocrinol. 11:980-985, 1997.
Perrin et al., Corticotropin releasing factor receptors and their ligand family, Ann. New York Acad. Sci., 885:312-328, Oct. 1999.
Pisarchik et al., Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression, FASEB J. 15(14):2754-2756, Dec. 2001.
Sakai et al., The genomic organizationof the human corticotropin-releasing factor type-1 receptor, Gene, 219:125-130, 1998.

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