Variants of bovine pancreatic trypsin inhibitor produced by reco

Details Variants of bovine pancreatic trypsin inhibitor produced by reco Variants of bovine pancreatic trypsin inhibitor produced by reco

1995-01-09

1998-06-23

Grimes, Eric

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3857, C07K 1481

Patent

active

057705682

ABSTRACT:
Peptides having essentially the sequence of bovine pancreatic trypsin inhibitor (aprotinin) wherein one or more of the amino acids at positions 15, 16, 17, 18, 34, 39 and 52 are replaced by any naturally occurring amino acid produced by recombinant DNA technology, process, expression vector and recominant host therefor and pharmaceutical use thereof. Such peptides being useful as therapeutic agents in diseases connected with the presence of excessive amounts of proteinases.

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