Variants and exons of the GlyT1 transporter

Details Variants and exons of the GlyT1 transporter Variants and exons of the GlyT1 transporter

2008-04-15

2008-04-15

Chernyshev, Olga N. (Department: 1649)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C435S243000, C435S252300, C536S023100, C536S023500, C530S350000

Reexamination Certificate

active

10484690

ABSTRACT:
The present invention provides polypeptide and polynucleotide sequences for novel splice variants of the sodium and chloride-dependent glycine transporter type 1 (GlyT1). These polypeptides and polynucleotides are useful in the treatment and diagnosis of disorders such as neurological and psychiatric disorders including schizophrenia. The invention also provides antibodies directed specifically against these novel polypeptides, and kits comprising the herein-described polynucleotides, polypeptides, and/or antibodies.

REFERENCES:
patent: 5968823 (1999-10-01), Borden et al.
patent: 0572287 (1993-01-01), None
patent: WO 94/23026 (1994-10-01), None
patent: WO 97/45423 (1997-12-01), None
patent: WO 98/18522 (1998-05-01), None
Barker, G.A. et al. “Neutral Amino Acid Transport in Bovine Articular Chondrocytes”,Journal of Physiology, 1999, pp. 795-808, vol. 514.3.
Bergeron, R. et al. “Modulation of N-methyl-D-aspartate Receptor Function by Glycine Transport”,Proc. Natl. Acad. Sci. USA, Dec. 1998, pp. 15730-15734, vol. 95.
Clark, J. et al. “Amino Acid Neurotransmitter Transporters: Structure, Function, and Molecular Diversity”,BioEssays, May 1993, pp. 323-332, vol. 15, No. 5.
Evans, J. et al. “Cloning, Functional Characterisation and Population Analysis of a Variant Form of the Human Glycine Type 2 Transporter”,FEBS Letters, 1999, pp. 301-306, vol. 463.
Green, P. et al. “The Role of Antisense RNA in Gene Regulation”,Ann. Rev. Biochem., 1986, pp. 569-597, vol. 55.
Horiuchi, M. et al. “Surface-localized Glycine Transporters 1 and 2 Function as Monomeric Proteins inXenopus oocytes”, PNAS, Feb. 13, 2001, pp. 1448-1453, vol. 98, No. 4.
Izant, J. et al. “Inhibition of Thymidine Kinase Gene Expression by Anti-Sense RNA: A Molecular Approach to Genetic Analysis”,Cell, Apr. 1984, pp. 1007-1015, vol. 36.
Kim, K. et al. “Cloning of the Human Glycine Transporter Type 1: Molecular and Pharmacological Characterization of Novel Isoform Variants and Chromosomal Localization of the Gene in the Human and Mouse Genomes”,Molecular Pharmacology, 1994, pp. 608-617, vol. 45.
Liu, Q. et al. “Cloning and Expression of a Glycine Transporter from Mouse Brain”,FEBS, 1992, pp. 110-114, vol. 305, No. 2.
Liu, W. et al. “Characterization of the Glycine Transport System GLYT 1 in Human Placental Choriocarcinoma Cells (JAR)”,Biochimica et Biophysica Acta, 1994, pp. 176-184, vol. 1194.
Nunez, E. et al. “Differential Effects of the Tricyclic Antidepressant Amoxapine on Glycine Uptake Mediated by the Recombinant GLYT1 and GLYT2 Glycine Transporters”,British Journal of Pharmacology, 2000, pp. 200-206, vol. 129.
Olivares, L. et al. “Analysis of the Transmembrane Topology of the Glycine Transporter GLYT1*”,The Journal of Biological Chemistry, Jan. 10, 1997, pp. 1211-1217, vol. 272, No. 2.
Olney, J. et al. “Glutamate Receptor Dysfunction and Schizophrenia”,Arch. Gen. Psychiatry, Dec. 1995, pp. 998-1007, vol. 52.
Rossi, J. et al. “The Potential Use of Catalytic RNAs In Therapy of HIV Infection and Other Diseases”,Pharmac. Ther., 1991, pp. 245-254, vol. 50.
Sczakiel, G. et al. “The Potential of Ribozymes as Antiviral Agents”,Trends in Microbiology, 1995, pp. 213-217, vol. 3, No. 6.
Tsen, G. et al. “Receptors with Opposing Functions are in Postsynaptic Microdomains Under One Presynaptic Terminal”,Nature Neuroscience, Feb. 2000, pp. 126-132, vol. 3, No. 2.
Uhl, G. “Neurotransmitter Transporters (plus): a Promising New Gene Family”,TINS, 1992, pp. 265-268, vol. 15, No. 7.
Sulston, J. et al. “Toward a complete human genome sequence”Genome Research, 1998, pp. 1097-1108, vol. 8, No. 11.
Armer, R.E. et al. “Inhibitors of Mammalian Central Nervous System Selective Amino Acid Transporters”,Current Medicinal Chemistry, 2000, pp. 199-209, vol. 7.

Affiliated with

Also associated with

Rating

Variants and exons of the GlyT1 transporter does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Variants and exons of the GlyT1 transporter, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Variants and exons of the GlyT1 transporter will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3918056