Variant Tat proteins and methods for use thereof

Details Variant Tat proteins and methods for use thereof Variant Tat proteins and methods for use thereof

2007-07-17

2007-07-17

Campell, Bruce R. (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C424S208100

Reexamination Certificate

active

10505265

ABSTRACT:
Variants of the HIV-1 Tat protein exhibiting higher transcriptional activation and stronger P-TEFb binding than wild-type Tat are provided. In addition variants that can inhibit transcription activation by wild-type Tat are provided. Nucleic acid sequences encoding these variants, vectors and host cells for expression of these variants, and antibodies raised against these variants are also provided. In addition, methods for use of these variants and compositions containing these variants as research tools, as diagnostic tools and in the treatment of viral infections are provided.

REFERENCES:
Roof, P. et al., Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kB and the Tat transactivator, Virology (2002), 296:77-83.
Reza et al., “A Naturally Occurring Substitution in Human Immunodeficiency Virus Tat Increases Expression of the Viral Genome”, Journal of Virology 2003 77 (15) :8602-8606.
NCBI Database Accession No. P05908 [gi:135350] Jun. 15, 2002.

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