Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-06-12
2007-06-12
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S501000
Reexamination Certificate
active
10749075
ABSTRACT:
A variant human α7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human α7 nAChR. Nucleic acid molecules encoding the variant human α7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
REFERENCES:
patent: 5202257 (1993-04-01), Heinemann et al.
patent: 5910582 (1999-06-01), Elliott et al.
patent: 9420617 (1994-09-01), None
L. E. Adler et al.,Biol. Psychiartry, vol. 32, 607-616 (1992).
M. H. Akabas et al.,Biochem., vol. 34, 12496-12500 (1995).
A. Akaike et al.,Brain Res., vol. 644, 181-187 (1994).
K. Aoshiba et al.,J. Lab. Clin. Med., vol. 127, 186-194 (1996).
M. Ballivet et al.,J. Mol. Biol., vol. 258, 261-269 (1996).
C. Beck et al.,Neurobiol. Disease, vol. 1 95-99 (1994).
C. Beck et al.,Epilepsia, vol. 36, S28 (1995).
D. Bertrand et al.,Proc. Natl. Acad. Sci.(USA), vol. 89, 1261-1265 (1992).
D. Bertrand et al.,Pro. Natl. Acad. Sci.(USA), vol. 90, 6971-6975 (1993).
D. Bertrand et al.,Sem. Neurosci., vol. 7, 75-90 (1995).
R. Blitzer et al.,Neurosci. Lett., vol. 119, 207-210 (1990).
J.-P. Changeux et al.,Trends Pharmacol. Sci., vol. 13, 299-301 (1992a).
J.-P. Changeux et al.,Q. Rev. Biophys., vol. 25, 395-432 (1992b).
J. Chen et al.,Biophys. J., vol. 69, 849-859 (1995).
S. Couturier et al.,Neuron, vol. 5, 847-856 (1990).
D. Donnelly-Roberts et al.,Brain Res., vol. 719, 36-44 (1996).
A. Engel et al.,Ann. Neurol., vol. 40, 810-817 (1996).
A. Ferrer-Montiel et al.,FEBS Lett., vol. 324, 185-190 (1993).
G. Filatov et al.,Mol. Pharmacol. vol. 48, 379-384 (1995).
R. Freedman et al.,J. Neurosci., vol. 13, 1965-1975 (1993).
R. Freedman et al.,Proc. Natl. Acad. Sci.(USA), vol. 94, 587-592 (1997).
J. Freeman et al.,Nature, vol. 269, 218-222, (1977).
K. Fuxe et al.,Clin. Investig., vol. 72, 262-268 (1994).
J.-L. Galzi et al.,FEBS Lett., vol. 294, 198-202 (1991).
J.-L. Galzi et al.,Nature, vol. 359, 500-505 (1992).
M. Garcia-Guzman et al.,Eur. J. Neurosci., vol. 7, 647-655 (1995).
M. Gopalakrishnan et al.,Eur. J. Pharmacol. -Mol. Pharmacol., vol. 290, 237-246 (1995).
F. Hory-Lee et al.,J. Neurosci., vol. 15, 6453-6460 (1995).
B. Hunter et al.,Neurosci. Lett., vol. 168, 130-134 (1994).
K. Imoto et al.,Nature, vol. 335, 645-648 (1988).
J. James et al.,Behav. Genet., vol. 25, 149-159 (1995).
A. Janson et al.,Neurosci., vol. 57, 931-941 (1993).
P. Kienker et al.,Biophys. J., vol. 66, 325-334 (1994).
R. Krause et al.,J. Physiol.(London), vol. 489, 779-790 (1995).
S. Leonard et al.,Schizophr. Bull., vol. 22, 431-445 (1996).
V. Luntz-Leybman et al.,Brain Res., vol. 587, 130-136 (1992).
P. Marin et al.,NeuroReport, vol. 5, 1977-1980 (1994).
E. Martin et al.,Drug Dev. Res., vol. 31, 135-141 (1994).
C. Newland et al.,J. Physiol. (London), vol. 487P, P 208 (1995a).
C. Newland et al.,J. Physiol. (London), vol. 489, 767-778 (1995b).
A. Owen et al.,NeuroReport, vol. 6, 2269-2272 (1995).
P. Pugh et al.,J. Neurosci., vol. 14, 889-896 (1994).
M. Quik et al.,Brain Res., vol. 655, 161-167 (1994).
F. Revah et al.,Nature, vol. 353, 846-849 (1991).
I. Rinner et al.,Biochem. Biophys. Res. Commun., vol. 203, 1057-1062 (1994).
S. Sawada et al.,Neurosci. Res., vol. 20, 317-322 (1994a).
S. Sawada et al.,Neurosci. Res., vol. 20, 323-329 (1994b).
S. Sine et al.,Neuron, vol. 15, 205-211 (1995).
O. Steinlein et al.,Nature Genetics, vol. 11, 201-203 (1995).
O. Steinlein et al.,Am. J. Med. Genet., vol. 74, 199-201 (1997).
K. Stevens et al.,Neuropsychopharmacol., vol. 15, 152-162 (1996).
J. Sullivan et al.,Soc. Neurosci. Abstr., vol. 22, 1263 (1996).
S. Tamamizu et al.,Cell. Mol. Neurobiol., vol. 15, 427-438 (1995).
M. Treinin et al.,C. elegans. Neuron, vol. 14, 71-877 (1995).
A. Villarroel et al.,Proc. R. Soc. Lond. [Biol.]. vol. 243, 69-74 (1991).
M. Wayner et al.,Peptides, vol. 17, 1127-1133 (1996).
K.J. Elliott, et al. J. of Molecular. Neuroscience, vol. 7, 217-228 (1996).
J.L. Galzi, Neuropharmacology, vol. 34, No. 6, 563-582 (1995).
Peng, X., et al., Molecular Pharmacology, vol. 45, No. 3 , 546-554 (1994 ).
Sequela, et al. J. Neuroscience vol. 13(2) 596-604-(1993).
Sambrook, et al., Molecular Cloning: A Laboratory Manual, 2nd Edition (1989) Cold Spring Harbor Press, USA, pp. 16.2 16.4.
Briggs Clark A.
Gopalakrishnan Murali
Mc Kenna David G.
Monteggia Lisa M.
Roch Jean-Marc
Abbott Laboratories
Dykema Gossett PLLC
Mueller Lisa V.
Ulm John
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