Vaccine against avian encephalomyelitis

Details Vaccine against avian encephalomyelitis Vaccine against avian encephalomyelitis

1989-10-12

1993-05-04

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 4352351, 435236, 435237, 435239, 435 701, 435245, A61K 3912, C12N 700

Patent

active

052080234

ABSTRACT:
A process for preparation of an attenuated strain of avian encephalomyelitis virus ("AEV") which may be used as a component of a protective vaccine, which comprises the steps of infecting chick embryo fibroblast ("CEF") cells with AEV, culturing the AEV-infected CEF cells until the AEV has become adapted to the CEF cells and then isolating the AEV product from the CEF cells for use in the vaccine. An attenuated AEV strain produced in this way, and tests showing use as a vaccine in chickens are also described.

REFERENCES:
Bennjean et al., Biological Abstracts, vol. 63, (2), Ref. No. 9254, 1976.
Nicholas et al., Research in Veterinary Science, vol. 40, pp. 118-122, 1986.
Nicholas et al., Arch. Virol., vol. 96, pp. 283-287, 1987.
Nicholas et al., Biological Abstracts, vol. 82 (1), Ref. No. 4932, 1986.
Nicholas et al., Biological Abstracts, vol. 85 (2), Ref. No. 22926, 1987.

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