Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1990-02-08
1994-12-27
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Lymphokine
4242791, 4242831, 514 8, 514885, 530322, 530806, 530815, 436543, A61K 3939
Patent
active
053763696
ABSTRACT:
This invention is directed to an adjuvant composition in the form of an emulsion which is comprised of an emulsion-forming amount of a non-toxic tetra-polyol or of a POP-POE block polymer and an immunopotentiating amount of a muramyldipeptide of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, where R and R.sub.1 are each independently H or acyl of 1 to 22 carbon atoms, R.sub.2 is optionally substituted alkyl or optionally substituted aryl, R.sub.3 is H, alkyl, or aryl, R.sub.4 is H or lower alkyl, X is L-alanyl, L-.alpha.-aminobutyryl, L-arginyl, L-asparginyl, L-aspartyl, L-cysteinyl, L-glutaminyl, L-glutamyl, glycyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-lysyl, L-methionyl, L-ornithinyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tyrosyl, L-tryptophanyl, or L-valyl, and Y is D-glutamine, D-isoglutamine or D-isoasparagine. This invention is also directed to a vaccine containing an antigen and an adjuvant composition of the invention. This invention is also directed to a process of preparing an adjuvant composition and a vaccine of the invention. This invention is also directed to a kit for extemporaneous preparation of an adjuvant composition and a vaccine of the invention.
REFERENCES:
patent: 4082736 (1978-04-01), Jones et al.
patent: 4606918 (1986-08-01), Allison et al.
patent: 4770874 (1988-09-01), Allison et al.
patent: 4772466 (1988-09-01), Allison et al.
"Formulation of Vaccine Adjuvant Muramyldipeptides. 3. Processing Optimization Characterization, and Bioactivity of an Emulsion Vehicle", Pharmaceutical Research (1989), No. 9, vol. 6, pp. 748-752.
Snippe, H., et al., Int. Archs. Allergy appl. Immuno, 1981, vol. 65, pp. 390-398.
Hunter, R., et al., The Journal of Immunology, 1981, vol. 127, No. 3, pp. 1244-1250.
Arnold, B., et al., Eur. J. Immunol., 1979, vol. 9, pp. 363-366.
Ellouz, F., et al., Biochem. & Biophys. Res. Comm., 1974, vol. 59, No. 4, pp. 1317-1325.
Ligate, D., et al., Pharmaceutical Research, 1989, vol. 6, No. 9, pp. 748-752.
Allison Anthony C.
Byars Noelene E.
Felgner Philip L.
Foster Linda C.
Fu Cherng-Chyi
Lee Lester L.
Roth Carol J.
Syntex (U.S.A.) Inc.
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