V-like domain binding molecules

Details V-like domain binding molecules V-like domain binding molecules

2007-01-23

2007-01-23

Gambel, Phillip (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S311000, C530S387300, C530S808000, C530S810000, C530S812000, C424S134100, C514S002600, C435S007100

Reexamination Certificate

active

09623611

ABSTRACT:
The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterized in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.

REFERENCES:
patent: 5434131 (1995-07-01), Linsley et al.
patent: 5504069 (1996-04-01), Bogden et al.
patent: 5728821 (1998-03-01), Yelton et al.
patent: 5773253 (1998-06-01), Linsley et al.
patent: 5792456 (1998-08-01), Yelton et al.
patent: 5792852 (1998-08-01), Do Couto et al.
patent: 5804187 (1998-09-01), Do Couto et al.
patent: 5844095 (1998-12-01), Linsley et al.
patent: 5849877 (1998-12-01), Ring
patent: 5851795 (1998-12-01), Linsley et al.
patent: 6383487 (2002-05-01), Amlot et al.
patent: 6521230 (2003-02-01), Amlot et al.
patent: 2003/0134386 (2003-07-01), Koide
patent: WO91/10438 (1991-07-01), None
patent: WO 92/01787 (1992-02-01), None
patent: WO 92/15671 (1992-09-01), None
patent: WO 93/00431 (1993-01-01), None
patent: WO 94/05690 (1994-03-01), None
patent: WO 94/12625 (1994-06-01), None
patent: WO 95/01994 (1995-01-01), None
patent: WO 96/06625 (1996-03-01), None
patent: WO 96/08564 (1996-03-01), None
patent: WO 96/18105 (1996-06-01), None
patent: WO 96/36714 (1996-11-01), None
patent: WO 96/39514 (1996-12-01), None
patent: WO 97/28267 (1997-08-01), None
patent: WO 98/33513 (1998-08-01), None
patent: WO 98/33513 (1998-08-01), None
Metzler et al. Nat. Structural Biol. 1997; 4(7):527-531.
Bajorath J. Mol. Model 1999; 5:169-170.
Nuttall et al. PROTEINS: Structure, Function , and Genetics 1999; 36:217-227.
Cai et al. Proc. Natl. Acad. Sci. USA 1996; 93:6280-6285.
Jung et al., Protein Engineering, vol. 10, No. 8, pp. 959-966, 1997.
Davies et al., Protein Engineering, Medline Abstract, vol. 9, No. 6, pp. 531-537, Jun. 1996
Peach et al., J. Exp. Med., vol. 180, pp. 2049-2058, Dec. 1994.
Patten et al., The Journal of Immunology, vol. 150, No. 6, pp. 2281-2294, Mar. 15, 1993.
Linsley et al. (1995) “Binding stoichiometry of the cytotoxic T lymphocyte—associated Molecule-4 (CTLA-4)” Journal of Biological Chemistry, vol. 270, No. 25, pp. 15417-15424.

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