Uses of didemnins as immunomodulating agents

Details Uses of didemnins as immunomodulating agents Uses of didemnins as immunomodulating agents

1998-07-07

2000-12-05

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 514 11, A61K 3812

Patent

active

061567248

ABSTRACT:
The present invention is based upon the immunomodulatory activity of synthetic and semi-synthetic didemnin compounds. It has surprisingly been discovered that certain didemnin compounds possess unexpectedly high immunomodulation activity, and thus will be useful for modulating or regulating immunological functions in warm blooded animals. From the data provided herein it is believed that the physician will be able to determine the appropriate dosage of the immunosuppressant didemnins of the present invention. The actual dosage to be administered depends, inter alia, on the animal species to be treated, the subject animal's size, and the capacity of the subject to utilize the particular didemnin compound administered. Accordingly, the actual amounts of any didemnin compound required to be administered depend on the judgment of the practitioner.

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patent: 5137870 (1992-08-01), Rinehart
patent: 5294603 (1994-03-01), Rinehart
patent: 5294604 (1994-03-01), Nussenblatt et al.

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