Anti-T cell receptor .gamma.-chain monoclonal antibody

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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43524027, 435 724, 935104, 53038875, C07K 300, C07K 1300, C07K 1500

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active

051699389

ABSTRACT:
Monoclonal antibodies are disclosed capable of reacting with T cell receptor .gamma.-chain and being useful as a reagent for investigating functions of T cell receptor .gamma.-chain.

REFERENCES:
Brenner, et al., "Identification of a Putative Second T-Cell Receptor", Nature 322, pp. 145-149 (Jul. 10, 1986).
Nakanishi, et al., "T .gamma. protein is expressed on murine fetal thymocytes . . . heterodimer", Nature 325, pp. 720-723 (Feb. 19, 1987).
Kranz, et al., "Limited Diversity of the Rearranged T-cell .gamma. Gene", Nature 313, pp. 752-755 (Feb. 28, 1985).
Lew, et al., "Characterization of T Cell Receptor . . . Thymocytes", Science 234, pp. 1401-1405 (Dec. 12, 1986).
Ioannides, et al. "Identification of a second T-cell antigen receptor . . . antibody", P.N.A.S. 84, pp. 4244-4248 (Jun. 1987).
Maeda et al. "Expression of the T-cell receptor . . . Reaction", P.N.A.S. 84, pp. 6536-6540 (Sep. 1987).
Nature, P. Moingeon, et al., "A Gamma-chain complex forms a functional receptor on cloned human lymphocytes with natural killer-like activity", vol. 325, No. 6106, pp. 723-726, (1987).
Nature, P. Moingeon, et al. , "A unique T-cell receptor complex expressed on human fetal lymphocytes displaying natural killer-like activity", vol. 323, No. 6087, pp. 638-640 (1986).

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