Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2007-04-03
2007-04-03
Henley, III, Raymond J (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
Reexamination Certificate
active
11012722
ABSTRACT:
The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for improving kidney functions, such as urine output, and treating symptoms associated with kidney malfunction or failure. The invention also relates to kits for the improvement of kidney functions and the treatment of symptoms associated with kidney malfunction or failure, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
REFERENCES:
patent: 4306075 (1981-12-01), Aristoff
patent: 5153222 (1992-10-01), Tadepalli et al.
patent: 6054486 (2000-04-01), Crow et al.
patent: 6441245 (2002-08-01), Moriarty et al.
patent: 6521212 (2003-02-01), Cloutier et al.
patent: 6528688 (2003-03-01), Moriarty et al.
patent: 2005/0080140 (2005-04-01), Hatae et al.
patent: 2005/0085540 (2005-04-01), Phares et al.
patent: 2005/0165111 (2005-07-01), Wade et al.
patent: 2005/0282901 (2005-12-01), Phares et al.
Clapp, L. H., et al., “Differential Effects of Stable Prostacyclin Analogs on Smooth Muscle Proliferation and Cyclic AMP Generation in Human Pulmonary Artery”, Am. J. Respir. Cell Mol. Biol., vol. 26, pp. 194-201 (2002).
Medline Plus® Medical Encyclopedia: Diabetic nephropathy, pp. 1-4, www.nlm.nih.gov/medlineplus/ency/article/000494.htm, date unavailable.
Medline Plus® Medical Encyclopedia: Immune response, pp. 1-3, www.nlm.nih.gov/medlineplus/ency/article/000821.htm, date unavailable.
Medline Plus® Medical Encyclopedia: Mesangial proliferative glomerulonephritis, pp. 1-3, www.nlm.nih.gov/medlineplus/ency/article/000487.htm, date unavailable.
Patterson, J. H., et al., “Acute Hemodynamic Effects of the Prostacyclin Analog 15AU81 in Severe Congestive Heart Failure”, The Amer. J. Card., vol. 75, pp. 26A-33A (1995).
Raychaudhuri, B., et al., “The Prostacyclin Analogue Treprostinil Blocks NFχB Nuclear Translocation in Human Alveolar Macrophages”, J. Biol. Chem., vol. 277, No. 36, pp. 33344-33348 (2002).
Shionoya, S., “Diagnostic criteria of Buerger's disease”, Intl. J. Cardio. 66 (Suppl. 1), pp. S243-245 (1998).
Tyle, P., “Iontophoretic Devices for Drug Delivery”, Pharma. Res., vol. 3, No. 6, pp. 318-326 (1986).
van Dijk, C., et al., “Pathogenesis of Diabetic Nephropathy”, Rev. in Endocrine & Metabolic Disorders, vol. 5, No. 3, pp. 237-248 (2004).
Bronstein Kathryn
Jeffs Roger Andrew
Strootman Deborah
Wade Michael
Foley & Lardner LLP
Henley, III Raymond J
United Therapeutics Corporation
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