Use of specific T2R taste receptors to identify compounds...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007210, C436S501000

Reexamination Certificate

active

07338771

ABSTRACT:
Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.

REFERENCES:
patent: WO 01/18050 (2001-03-01), None
Parry-CM et al., PNAS 101(14830-14834)2004.
Bufe-B et. al., Nature Genetics 32(397)2002.
Conte-C. et al., Cytogenet. Genomic Res. 98(45-53)2002.
Shi-P et al., Mol Biol Evol. May 2003;20(5):805-14.
Bowie et al., 1990, Science 247:1306-1310.
Guo-HH et al. PNAS 101(25)9205-9210, 2004.

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