Use of preparation comprising a plasminogen activator to improve

Details Use of preparation comprising a plasminogen activator to improve Use of preparation comprising a plasminogen activator to improve

1997-08-04

1999-07-20

Lankford, Jr., Leon R.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 943, 424 9464, 514925, 514928, A61K 3848

Patent

active

059253509

ABSTRACT:
The present invention relates to the use of non-bacterial plasminogen activators in the manufacture of a topical medical preparation for the treatment of slow- or non-healing wounds. In addition, the present invention relates to a composition comprising a physiologically acceptable carrier and an effective amount of a non-bacterial plasminogen activator, with the exclusion of t-PA. Finally, the present invention is directed to a method of treatment of slow- or non-healing wounds comprising the topical application of a non-bacterial plasminogen activator to the site of a wound.

REFERENCES:
patent: 4929442 (1990-05-01), Powell
patent: 5192743 (1993-03-01), Hsu et al.
patent: 5364622 (1994-11-01), Franz et al.
Grondahl-Hansen et al. J. Invest. Dermatol. vol. 8, pp. 790-795, Abstract enclosed, 1988.
Quax et al., Plasminogen activators are involved in keratinocyte and fibroblast migration in wounded cultures in vitro, Fibrinolysis, vol. 8, pp. 221-228, 1994.
M.C. Stacey, et al; "Tissue and Urokinase Plasminogen Activators in the Environs of Venous and Ischaemic Leg Ulcers", The British Journal of Surgery, vol. 80, No. 5, May 1993, pp. 596-599.

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