Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Reexamination Certificate
2009-01-23
2010-10-05
Swartz, Rodney P. (Department: 1645)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
C424S009100, C424S130100, C424S150100, C424S163100, C424S164100, C424S184100, C424S234100, C424S257100, C424S258100, C424S259100
Reexamination Certificate
active
07807139
ABSTRACT:
The present invention provides a method for the treatment and/or prevention of bacterial infection caused byKlebsiella pneumoniaeand other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused byEnterobacteriaceaefamily in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused byEnterobacteriaceaefamily in central nervous system and/or peripheral blood circulation in a mammal.
REFERENCES:
Wertz, J.E., et al. A molecular phylogeny of enteric bacteria and implications for bacterial species concept. J. Evol. Biol. vol. 16, pp. 1236-1248, 2003.
Nguyen, T.N. et al, Chromosomal sequencing using a PCR-based biotin-capture method allowed isolation of the complete gene for the outer membrane protein A ofKlebsiella pneumoniae, Journal, 1998, Gene 210, pp. 93-101, Elsevier.
Jeannin, P. et al, Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen presenting cells-impact on vaccine strategies, Journal, 2002, Vaccine 20, pp. A23-A27, Elsevier.
Ho Yuan-Soon
Hsieh Wen-Shyang
Hsu Shih-Lan
Huang I-Jen
Huang Shih-Yi
King Anthony
Swartz Rodney P.
Taipei Medical University
WPAT, P.C.
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