Use of motionless mixer as cell culture propagator

Details Use of motionless mixer as cell culture propagator Use of motionless mixer as cell culture propagator

1980-07-07

1981-10-20

Rosen, Sam

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435241, C12M 700

Patent

active

042962048

ABSTRACT:
Use of a static mixing system element as a tissue culture propagator. The element comprises an assembly of parallel sheets shaped to provide a plurality of mixing cells wherein fluid entering a cell from two separate inlet channels is rearranged due to shearing and extensional forces and divided into two new outlet streams each of which leaves the mixing cell in a different direction from either inlet stream. The configuration of the device provides uniform flow across all surfaces for precise control of growth conditions and maximum cell growth.

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Rudiger, "Methods in Cell Biology,"Academic Press, 1975, vol. 9, pp. 13-23.
McCoy et al., "Class Helix Perfusion Chamber for Massive Growth of Cells in Vitro," Proc. Soc. Biol. Med., 1962, vol. 109, pp. 235-237.

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