Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2006-04-04
2006-04-04
Falk, Anne-Marie (Department: 1632)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C424S093100, C424S093200
Reexamination Certificate
active
07022321
ABSTRACT:
The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell.The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein.Isolated recombinant cells and a pharmaceutical composition are also provided.
REFERENCES:
patent: 5716616 (1998-02-01), Prockop et al.
patent: WO 99/43286 (1999-09-01), None
Cao et al. (2002) Stem cell repair of central nervous system injury. Journal of Neuroscience Research 68: 501-510.
Friedmann, T. (1997) Overcoming the obstacles to gene therapy. Scientific American, Jun. 1997, pp. 96-101.
Mehler et al. (1999) Progenitor cell biology: Implications for neural regeneration. Archives of Neurology 56(7): 780-784.
Milward et al. (1997) Isolation and transplantation of multipotential populations of epidermal growth factor-responsive, neural progenitor cells from the canine brain. Journal of Neuroscience Research 50: 862-871.
Orkin and Motulsky (1965) Report and recommendation of the panel to assess the NIH investment in research on gene therapy pp. 1-38, availabe at http://www.nih.gov
ews/panelrep.html.
Ross et al. Gene therapy in the United States: A five year status report. Human Gene Therapy 7: 1781-1790.
Rossi and Cattaneo (2002) Neural stem cell therapy for neurological diseases: dreams and reality. Nature Reviews Neuroscience 3: 401-409.
Rubanyi, GM (2001) The future of human gene therapy. Molecular Aspects of Medicine 22: 113-142.
Verma et al. (1997) Gene therapy—promises, problems and prospects. Nature 389: 239-242.
Altman, J.,TINS17(2):47-49, 1994.
Banati et al., “A Subpopulation of Bone Marrow-Derived Macrophage-Like Cells Shares a Unique Ion Channel Pattern with Microglia,”J. Neuroscience Research30(4): 593-600, Dec. 1991, Abstract only.
Brazelton, T.R., et al., “From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice,”Science290:1775-1779, 2000.
Eglitis et al., “Contribution of Bone Marrow-Derived Cells to Lesion-Associated Gliosis in the Adult CNS,”Soc. Neurosci. Abstr.22:1691, 1997. Abstract.
Eglitis et al., “Ex Vivo GDNF Gene Transfer Using Marrow Cells in Rodent Models of Dopaminergic Neurodegeneration,”Soc. Neurosci. Abstr.24:1222, 1998. Abstract.
Eglitis et al., “Hematopoietic Cells Differentiate Into Both Microglia and Macroglia in the Brains of Adult Mice,”Proc. Natl. Acad. Sci. USA94:4080-4085, Apr. 1997.
Eglitis et al., “Targeting of Marrow-Derived Astrocytes to the Ischemic Brain,”NeuroReport10:1289, 1999.
Fedoroff, S., “Development of Microglia,” inNeuroglia, eds. Kettenmann, H. & Ransom, B. R. (Oxford University Press, New York), pp. 162-181, 1995.
Learish et al., “Retroviral Gene Transfer and Sustained Expression of Human Arylsulfatase A,”Gene Therapy3(4):343-349, Apr. 1996.
Lewis, P. D., “The Fate of the Subependymal Cell in the Adult Rat Brain, with a Note on the Origin of Microglia,”Brain. 91:721-738, 1968.
Ling, E.-A. and Wong, W.-C., “The Origin and Nature of Ramified and Amoeboid Microglia: A Historical Review and Current Concepts,”Glia. 7:9-18, 1993.
Kitamura, T., Miyake, T. & Fujita, S., “Genesis of Resting Microglia in the Gray Matter of Mouse Hippocampus,”J. Comp. Neurol. 226:421-433, 1984.
Krall, W.J., et al., “Cells Expressing Human Glucocerebrosidase From a Retroviral Vector Repopulate Macrophages and Central Nervous System Microglia After Murine Bone Marrow Transplantation,”Blood83(9):2737-2748, 1994.
Maréchal, V., et al., “Disappearance of Lysosomal Storage in Spleen and Liver of Mucopolysaccharidosis VII Mice After Transplantation of Genetically Modified Bone Marrow Cells,”Blood82(4):1358-1365, 1993.
Mezey, E., et al., “Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated In Vivo from Bone Marrow,”Science290:1779-1782, 2000.
Mouradian, M.M., et al., “Protection of Nigral Neurons by GDNF-Engineered Marrow Cell Transplantation in the Mouse MPTP Model,”Mov. Disord. 15(Suppl. 3):15, 2000. Abstract.
Neuhaus, J. & Fedoroff, S., “Development of Microglia in Mouse Neopallial Cell Cultures,”Glia. 11:11-17, 1994.
Park, K-W, et al., “Protection of Nigral Neurons by GDNF-Engineered Marrow Cell Transplantation,”Neuroscience Research40:315-323, 2001.
Perry, V. H. & Gordon, S., “Macrophages and Microglia in the Nervous System,”TINS11(6):273-278, 1988.
Skoff, R. P. & Knapp, P. E., “The Origins and Lineages of Macroglial Cells,” inNeuroglia, eds. Kettenmann, H. & Ransom, B. R. (Oxford University Press, New York), pp. 135-148, 1995.
Snyder et al., “The Use of Nonneuronal Cells for Gene Delivery,”Neurobiol. Dis. 4(2):69-102, 1997.
Theele, D. P. & Streit, W. J., “A Chronicle of Microglial Ontogency,”Glia. 7:5-8, 1993.
Unger, E.R., et al., “Male Donor-Derived Cells in the Brains of Female Sex-Mismatched Bone Marrow Transplant Recipients: A Y-Chromosome SpecificIn SituHybridization Study,”Journal of Neuropathology and Experimental Neurology52(5):460-470, 1993.
Zlokovic, B.V., et al., “Cellular and Molecular Neurosurgery: Pathways From Concept to Reality—Part I: Target Disorders and Concept Approaches to Gene Therapy of the Central Nervous System,”Neurosurgery40(4):789-804, Apr. 1997.
Zlokovic, B.V., et al., “Cellular and Molecular Neurosurgery: Pathways From Concept to Reality—Part II: Vector Systems and Delivery Methodologies for Gene Therapy of the Central Nervous System,”Neurosurgery40(4):805-813, Apr. 1997.
Eglitis Martin A.
Mezey Eva
Mouradian Mary Maral
Falk Anne-Marie
Klarquist & Sparkman, LLP
LandOfFree
Use of marrow-derived glial progenitor cells as gene... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of marrow-derived glial progenitor cells as gene..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of marrow-derived glial progenitor cells as gene... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3576550