Use of catechol-O-methyl transferase (COMT) inhibitors and their

Details Use of catechol-O-methyl transferase (COMT) inhibitors and their Use of catechol-O-methyl transferase (COMT) inhibitors and their

1988-12-23

1991-03-19

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514520, 514557, 514731, 514737, 514925, 514926, 514927, 558412, 560130, A61K 31235, A61K 31275, C07C25500, C07C 6900

Patent

active

050011529

ABSTRACT:
The invention is concerned with the new use of known catechol derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms; X is nitro, halogen or cyano and R.sub.3 is chlorine, nitro, cyano or a radical of the formula ##STR2## wherein R.sub.4 is hydrogen, cyano, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms and R.sub.5 is cyano, alkanoyl having 2 to 5 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, carboxyl or phenylcarbonyl unsubstituted or substituted with one to three methoxy groups or pharmaceutically acceptable salt thereof. The new use is the treatment and prophylaxis of ulcers and lesions in the gastrointestinal tract.

REFERENCES:
patent: 4436752 (1984-03-01), Christidis et al.
patent: 4760089 (1988-07-01), Chambers et al.
Chemical Abstracts, vol. 102, No. 9, Mar. 4, 1985, Abstract 72397g, Barnaulov O.D.
Backstrom et al. "Synthesis . . . ", CA 110:172835g (1989).
Backstrom et al, "Preparation . . . ", CA 109:128570x (1988).
Iida et al, Chemical Abstracts vol. 79:105449n, p. 447 (1973).
Castello et al, Chemical Abstracts, vol. 104:109112e, p. 676 (1986).
Vellaccio et al, Chemical Abstracts, vol. 95:42542v, p. 710 (1981).
Umemura et al, Chemical Abstracts, vol. 92:146461x, p. 560 (1980).
Firnau et al, Chemical Abstracts, vol. 79:27554b, p. 65 (1973).
Windholz et al, The Merck Index, p. 1022 (1976), Items 7678 and 7679.

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